Progesterone sensitivity. . I see some degree of progesterone intolerance in about 20% of my patients. Once you determine that you may have some degree of progesterone intolerance, the next step is to figure out what progesterone you can use if you have a uterus and you're on estrogen. . Norethindrone (aygestin), Levonorgestrol, and Duavee are all good options, as is the IUD! Remember one size does not fit all and just because your bestie loves progesterone does not mean it will work the same fo