Phosphorylated tyrosine occurs in proteins that are part of signal transduction processes. Similar functionality is also presented in serine and threonine, whose side chains have a hydroxy group, but are alcohols.

In biochemical contexts, the term "tyrosine" refers specifically to its functional group or side chain. Fig. 1. Structure of tyrosine. While typically categorized as a hydrophobic amino acid, tyrosine is more hydrophilic than phenylalanine. In the genetic code, it …

The aromatic side chain can also mean that Tyrosine is involved in stacking interactions with other aromatic side-chains. Role in function: Unlike the very similar Phenylalanine , Tyrosine contains a reactive hydroxyl group, thus making it much more likely …

Static Conformational Distributions in the Solid State: Analysis and Application to Angular Dispersion in Side Chain Orientations in Model Tyrosine in Aqueous Glass. The Journal of Physical Chemistry 1996, 100 (11) , 4654-4661. https://doi.org/10.1021/jp952515w

In this work, we used NMR spectroscopy to identify and characterize intermolecular hydrogen bonds between tyrosine (Tyr) side-chain hydroxyl (OH) groups and DNA phosphates in a protein-DNA complex.

2020年11月3日 · Herein we synthesized and characterized a variety of anionic pentameric oligothiophenes with different substitution patterns of L‐ or D‐tyrosine at distinct positions along the thiophene backbone.

2016年10月5日 · Current investigation revealed that the tyrosine side chain attained two different critical stereo orientations in two dissimilar conformational states of the peptide. The extended α-helical structure of the peptide observed in an apolar solvent or methanol/water mixture became disordered in aqueous medium and the radius of gyration decreased.

2012年4月15日 · Quantum chemical calculations demonstrate that this proton transfer is catalyzed by the tyrosine side chain ring for the YG a 2 ion. Isomer specific IRMPD bands observed in the two spectral regions clearly show the presence of the cyclic and rearranged ‘imine–amide’ isomers, the latter being characterized by an IR signature at ∼3545 cm ...

2021年9月1日 · Site-directed mutation of Trp 381 to Phe 381 significantly reduces the yields of Tyr side chain cleavage products, underlining a critical role of Trp for these reactions. Likewise, conformational changes of IgG4-Fc induced by increasing contents of 1-propanol in the solution diminishes the yields of Tyr side chain cleavage products.

2007年11月20日 · In this study, we have performed density functional theory (DFT) calculations for various hydrogen-bonded complexes of p-cresol, a simple model of a Tyr side chain, in different hydrogen-bond forms to develop explicit criteria for determining the hydrogen-bond structures of Tyr using FTIR spectroscopy.