CCL17 - Wikipedia
While type 2 helper T (Th2) cells are a key component of AD because they are localized to the skin through the CCL17-CCR4 interaction, memory Th17 cells seem to express high levels of CCR4 in both human and murine models of MS and are therefore likely candidates for …
The chemokine CCL17 is a novel therapeutic target for ... - Nature
2023年4月19日 · Our previous study demonstrated the involvement of helper T (Th) cells in CCL17 function during cardiac aging. 6 Indeed, Ccl17 knockout reduced aging-induced infiltration of total immune...
The role of the Th2 CC chemokine ligand CCL17 in pulmonary …
2004年10月1日 · Immunolocalization of bleomycin-treated lung tissue and human idiopathic pulmonary fibrosis tissue specimens showed that epithelial cells expressed CCL17. These findings demonstrate a central role for Th2 chemokines and the macrophage in the pathogenesis of pulmonary fibrosis and are further support for the role of a Th2 phenotype in the ...
What does elevated TARC/CCL17 expression tell us about
2021年5月19日 · By binding to C-C chemokine receptor type 4 (CCR4), which is, inter alia, expressed by Th2 cells , TARC/CCL17 participates in trafficking of Th2 cells in eosinophil-associated disorders including AA and AD and presumably of neoplastic cells in certain T cell lymphomas (e.g., angioimmunoblastic T cell lymphoma (AITL), mycosis fungoides (MF), and ...
CCL17 drives fibroblast activation in the progression of pulmonary ...
2023年4月1日 · Thymus- and activation-regulated chemokine (CCL17) is a Th2-type chemokine that is involved in Th2-dominant diseases such as bronchial asthma, atopic dermatitis and eosinophilic pneumonia [11], [12], [13], [14]. Several studies have revealed the upregulated expression of CCL17 in PF patients and animal models.
Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2 ...
TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the ker …
CCL17/TARC in autoimmunity and inflammation—not just a T‐cell …
2023年3月28日 · CCL17 is a C–C chemokine receptor type 4 (CCR4) ligand, with chemokine (C–C) ligand 22 being the other major ligand and, as CCR4 is highly expressed on helper T cells, CCL17 can play a role in T-cell–driven diseases, usually considered to be via its chemotactic activity on T helper 2 cells; however, given that CCR4 is also expressed by ...
Dectin-1 Controls TSLP-Induced Th2 Response by Regulating ... - PubMed
2021年7月7日 · The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L and CCL17 expression by myeloid dendritic cells (mDCs), which contributes to aberrant Th2-type immune responses.
An Atlas of Human Regulatory T Helper-like Cells Reveals Features …
2017年7月18日 · Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation
CCL17 acts as an antitumor chemokine in micromilieu‐driven …
2023年5月1日 · Our study has generated experimental models to dissect the roles of CCL17 and CCL22 in tumor microenvironments and provided direct evidence for CCL17-mediated antitumor functions by recruitment of conventional T cells, NKT cells, and NK cells.