2023年5月29日 · Tacrolimus is an immunosuppressive agent used for prophylaxis of organ rejection post-transplant. Tacrolimus use is in combination with one or, most commonly, two other immunosuppressive medications. It has an application as an agent for the prevention or treatment of certain autoimmune diseases.

Cyclosporine and tacrolimus selectively inhibit calcineurin, thereby impairing the transcription of interleukin (IL)-2 and several other cytokines in T lymphocytes. Calcineurin inhibitors have been mainstays of immunosuppression in solid organ transplantation for over three decades.

Tacrolimus, formerly known as FK506, is a macrolide antibiotic with immunosuppressive properties. Although structurally unrelated to cyclosporin A (CsA), its mode of action is similar. It exerts its effects principally through impairment of gene expression in target cells.

2015年12月31日 · Tacrolimus has similar activity to cyclosporine but rates of rejection are lower with tacrolimus. Tacrolimus has also been shown to be effective in the topical treatment of eczema, particularly atopic eczema.

Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogenic organ transplant , the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given.

Tacrolimus is a macrolide calcineurin inhibitor immunosuppressant drug available as a topical ointment, oral capsule, and intravenous injection. It was initially isolated from the soil fungus Streptomyces tsukabaenis. Who uses tacrolimus? What are the contraindications with tacrolimus?

2020年2月17日 · Suppresses cellular immunity (inhibits T-lymphocyte activation), by binding to an intracellular protein, FKBP-12 and complexes with calcineurin dependent proteins to inhibit calcineurin phosphatase activity.

2023年5月29日 · This activity outlines the indications, action, and contraindications for tacrolimus as a valuable agent in preventing solid-organ transplant rejection (and other disorders when applicable).

Tacrolimus is a macrolide immunosuppressant produced by the soil bacterium Streptomyces tsukubaensis. It is used intravenously and orally for the prevention of organ rejection after liver or kidney transplantation.

2024年11月25日 · Tacrolimus Capsules USP is a medicine that affects your immune system. Tacrolimus Capsules USP can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving Tacrolimus Capsules USP that can cause death.