The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, ...

In this paper, we described the pharmacological and toxicological studies of three pyrazolone derivatives namely PYZ1: 4- [4-N dimethylamino benzylidine]-3-methyl pyrazolin-5 (4H)-one, PYZ2: 4-...

2022年8月15日 · The reaction between ethyl acetoacetate and phenyl hydrazine led to the development of a new structure of first pyrazolone based drug, known in 1887 as 1-phenyl-3-methyl-5-pyrazolone (antipyrine). As the name suggests, it was the primary drug used to treat joint and musculoskeletal disorders, arthritis and fever.

Some 1-(4-chlorophenyl or benzenesulfonamide)-2,3- and/or 4-substituted-1H-pyrazol-5(4H)-one deriva-tives were synthesized and screened for their anti-inflammatory and analgesic activities, in addition to their ulcerogenic liability. They were found to be active as anti-inflammatory and analgesic agents. Compound 6b

2003年7月5日 · Pyrazolones delegate a cluster of compounds with the nucleus of 1H-pyrazol-3-ol and pyrazolin-5-one (Fig. 1) which have been investigated because of their multiple features and applications. Since 1883, the synthesis of antipyrine (1) by Knorr, numerous attention has caused by the analgesic and antipyretic activities of pyrazolone analogues [1].

Phenazone, propyphenazone, ampyrone and metamizole sodium are useful pyrazolone drugs as antipyretic and analgesic [2], whilst edaravone (MCI-186) has been...

Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.

Pyrazole is a versatile lead molecule; its derivatives are reported to possess innumerable biological activities such as anti-microbial, anti-fungal, anti-tubercular, anti-inflammatory, anti-convulsant, anticancer, anti-viral, angiotensin converting enzyme (ACE) inhibitory, neuroprotective, cholecystokinin-1 receptor antagonist, and estrogen ...

2020年1月15日 · The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on.

Pyrazolone | C3H2N2O | CID 11513733 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.