Pyrazolone is 5-membered heterocycle containing two adjacent nitrogen atoms. It can be viewed as a derivative of pyrazole possessing an additional carbonyl (C=O) group. Compounds containing this functional group are useful commercially in analgesics and dyes. [1]

Pyrazolone | C3H2N2O | CID 11513733 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, ...

Pyrazolone and its derivatives are an important class of heterocyclic compounds that occur in many drugs. They represent an interesting template for combinatorial and medicinal chemistry due to their simple preparation and wide biological actions including antipyretic, antibacterial, antifungal, analgesic, uricosuric, antiarthritic, anti ...

2022年8月15日 · Pyrazolone is a well-known influential synthon for the synthesis of many molecules which hold remarkable potential in the advancement of functional materials, coordination chemistry, and pharmaceutical chemistry.

A series of pyrazolone compounds as potential SARS-CoV-2 inhibitors were designed and synthesized. Employing computational techniques, the inhibitory potentials of the designed compounds against both spike protein and hACE2 were evaluated.

New derivatives of the pyrazolone nucleus were synthesized, characterized, and evaluated by spectroscopic analysis including FT-IR (with a prominent peak at 2922 (C-H str, CH)), 1 HNMR, and 13 C NMR. Elemental analysis, M.W, M.P, and R f values were also carried out.

2023年1月18日 · The pyrazolone class comprises a variety of hybrid compounds displaying diverse biological actions. Although studied for decades, these compounds are still of interest due to their facile chemical transformations.

2020年1月15日 · The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on.

…in the 19th century—salicylic acid, pyrazolone, and phenacetin (or acetophenetidin). Although chemically unrelated, the drugs in these families have the ability to relieve mild to moderate pain through actions that reduce inflammation at its source.