A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted . [3] [4]

2021年10月25日 · A prodrug is an inactive medication, but once it enters the body, the body turns it into an active form so that the medication can have its intended effect. This article will provide a definition of a prodrug, examples, and explain its use in medicine.

Prodrugs are bioreversible derivatives of drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert its...

Prodrug is a compound with little or no pharmacological activity that metabolizes inside the body and converts into a pharmacologically active drug compound. Prodrugs are designed to overcome pharmaceutical, pharmacokinetic, and/or pharmacodynamic challenges.

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug development.

This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism.

Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity.

2024年4月2日 · Prodrugs are molecular derivatives of active pharmaceutical ingredients (APIs) with little or no expected biological activity themselves, but they exhibit beneficial properties compared...

2018年4月27日 · In this Review, we highlight prodrug design strategies for improved formulation and pharmacokinetic and targeting properties, with a focus on the most recently marketed prodrugs. We also...

2022年1月1日 · Prodrug strategies can be considered a chemistry-enabled tool to overcome deficiencies in the physicochemical properties of a molecule that limit its formulation options or result in suboptimal bioavailability or safety profile and, consequently, pharmacological response.