Polymyxins are antibiotics. Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. They work mostly by breaking up the bacterial cell membrane. They are part of a broader class of molecules called nonribosomal peptides.

2024年7月3日 · Polymyxin B/trimethoprim ophthalmic kills certain types of bacteria by blocking their ability to create proteins or other substances that they need to grow and reproduce and by weakening their...

2023年7月4日 · Polymyxins are a class of medications used in the management and treatment of systemic infections caused by susceptible strains of multidrug-resistant organisms such as Pseudomonas aeruginosa. It is in the antibiotic class of drugs.

2023年12月8日 · Easy-to-read patient leaflet for Polymyxin B. Includes indications, proper use, special instructions, precautions, and possible side effects.

Polymyxins are bactericidal drugs that bind to lipopolysaccharides (LPS) and phospholipids in the outer cell membrane of gram-negative bacteria.

Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. [1] While it is useful for many Gram negative infections, it is not useful for Gram positive infections. [ 1 ]

2017年11月9日 · Polymyxin B (polymyxin b sulfate) is an antibiotic used to treat bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections. Polymyxin B is available in generic form. Common side effects of Polymyxin B include: temporary blurred vision if used as eye drops.

Polymyxins, the cationic lipopeptide antibiotics, discovered more than half a century ago, are considered to be the last-line of antibiotics available at the moment. This antibiotic shows a great bactericidal effect against Gram-negative bacteria. Polymyxins primarily target the bacterial membrane and disrupt them, causing lethality.

polymyxin, any of five polypeptide antibiotics derived from various species of soil bacterium in the genus Bacillus that are active against gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa.

Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria.