2017年5月1日 · Immune-mediated myopathies (IMMs) are a heterogeneous group of acquired muscle disorders characterized by muscle weakness, elevated creatine kinase levels, and myopathic electromyographic findings. Most IMMs feature …

Inflammatory myopathies may be associated with increased frequency of Myocardial infarction; Stroke; Risk increased with: Associated hypertension or lipid disorders Risk reduced with: Non-steroidal immunosuppressive treatment GI Esophageal Frequency: 37%; Skeletal or smooth muscle involvement Treatment: IVIg may be effective in refractory cases

2024年7月19日 · There are four distinct conditions considered to be idiopathic inflammatory myopathies 1,2: dermatomyositis. amyopathic dermatomyositis. hypomyopathic dermatomyositis. sporadic inclusion body myositis. immune-mediated necrotizing myopathy. anti-synthetase syndrome. Polymyositis was historically classified as an idiopathic inflammatory myopathy ...

Immune-Mediated Myopathy is defined as a condition in horses characterized by rapid muscle wasting, lethargy, stiffness, weakness, and fever, with histiocytic and lymphocytic infiltration of muscles observed in biopsies. It differs from similar conditions in humans and dogs by the types of T cells involved and the response to corticosteroid ...

2016年8月7日 · The infectious inflammatory myopathies can be split up into viral, parasitic, fungal, and bacterial myopathies. Apart from infectious myositis via the direct infection of skeletal muscle, microorganisms may also cause myositis past immune mechanisms.

2024年9月1日 · Immune-mediated necrotizing myopathy (IMNM) is a rare and newly recognized autoimmune disease within the spectrum of idiopathic inflammatory myopathies. It is characterized by myositis-specific autoantibodies, elevated serum creatine kinase levels, inflammatory infiltrate, and weakness.

Idiopathic inflammatory myopathies are categorized by muscle symptoms and associated autoantibodies. They include antisynthetase syndromes, dermatomyositis, polymyositis, myositis resulting from a rheumatic disease or overlap syndrome, inclusion body myositis (IBM), and immune-mediated necrotizing myopathy.

The major forms of autoimmune myopathies include dermatomyositis (DM), polymyositis (PM), myositis associated with antisynthetase syndrome (ASS), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM).

Randomly distributed necrotic muscle fibers without mononuclear cell infiltrates represent the histopathological hallmark of immune-mediated necrotizing myopathy; meanwhile, endomysial inflammation and muscle fiber degeneration are the two main pathological features in sporadic inclusion body myositis.

2023年3月22日 · Necrotizing autoimmune myopathy (NAM) is a rare subset of idiopathic inflammatory myopathies with a clinical presentation of severe proximal muscle weakness, elevated creatine kinase, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement .