2015年5月7日 · Oxantel pamoate, an m-oxyphenol derivative, can be given in a single dose for Trichuris spp. Pyrantel pamoate and its analogs act by causing depolarizing neuromuscular blockade and by blocking acetylcholinesterase, which result in spastic paralysis and muscle contracture, respectively, and allow expulsion of the worms.

Pyrantel Pamoate. Pyrantel pamoate is an excellent choice for eliminating nematodes if the amphibian may be orally medicated. A typical dose is 5 to 10 mg/kg PO repeated every 7 days for 28 days. A combination of pyrantel pamoate and praziquantel (Drontal) has been used, and the dosage is determined by the amount of pyrantel pamoate. Ivermectin

2016年1月1日 · Pyrantel pamoate (Strongid, Nemocid) may be used for the treatment of hookworms and roundworms in humans, pets, and other animals with effects that can vary according to parasite species and resistance status [3]. Hookworms and Trichuris species are typically less susceptible to pyrantel than Ascaris species and related roundworms [3].

In mass treatment programs, WHO allows the use of pyrantel pamoate in the 2nd and 3rd trimesters of pregnancy in the endemic regions, although the effects of pyrantel on birth outcomes are uncertain. Individuals with underlying hepatic disease are more susceptible to toxicity. LD 50 in rats is 535 mg/kg. Adverse drug reactions (ADRs)

1992年2月1日 · RESI;I.TS Zinc sulfate flotations showed that all dogs were helminth-free at the start of the study, but 14 of 16 dogs had Giardia spp. cysts in their stools at some point during the study. The ivermectin/pyrantel pamoate combination was 99.6% effective against both U. stenocephala and A. caninum (P<0.01 com- pared with control).

1971年1月1日 · DRUG STANDARD Spectrophotometric Determination of Pyrantel in Pyrantel Pamoate Bulk Samples and Pharmaceutical Formulations George A. Forcier, Robert F. Mushinsky, Richard L. Wagner, Jr. Analytical Research Department, Pfizer Medical Research Laboratories, Groton, CT 06340 Analytical Research Department, Pfizer Medical Research …

1998年2月27日 · For sample preparation, SPE was used. Simultaneous determination of fenbendazole and praziquantel was carried out by RP-HPLC with ultraviolet detection at 220 nm. Assay of pyrantel pamoate using a base-deactivated reversed-phase column without using ion-pairing or silanol-masking reagents is also reported.

1998年5月14日 · The particle size data for the pyrantel pamoate were characterized by a geometric mean volume diameter of 9.53 μm, and a geometric standard deviation 1.73 μm. Fig. 1 shows the fit of the Eq. (1) to the isotherm for the adsorption of polysorbate 80 on these pyrantel pamoate particles obtained at 25°C, a standard value of temperature for the ...

2023年8月1日 · Praziquantel and pyrantel pamoate reduced anoplocephalid egg counts by 23.5 and 50.9%, respectively. • Praziquantel eliminated anoplocephalid eggs from 3 of 17 horses. • Pyrantel pamoate did not eliminate anoplocephalid eggs from any of the 14 tapeworm-positive horses. • Strongylid egg count data suggested resistance to both ivermectin ...

2006年4月15日 · The pamoate salt of pyrantel is practically insoluble in water (<0.1 mg/mL water between 15 and 25 °C; European Pharmacopeia, 2005). This property offers the advantage of reduced absorption from the gastrointestinal tract of horses and allows the drug to reach the microenvironmental sites of the target parasites.