Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the …

2017年1月1日 · Iodine plays a key role in the regulation of thyroid function and thyrocyte proliferation, and this phenomenon is called “autoregulation.” Excess iodine causes reduced …

Iodide is a major regulator of iodide accumulation and organification. Iodine intake has a negative effect on the expression of NIS and high doses of iodide block thyroid hormone synthesis via …

Uptake and organification of iodine by the thyroid gland. Active uptake of iodide (I-) in exchange for Na +. Iodide may be discharged from the follicular cell by administration of competing ions …

2019年7月15日 · Myo-inositol, a carbocyclic polyol, regulates the generation of hydrogen peroxide (H 2 O 2) in thyrocytes, crucial for iodine organification and thyroid hormone biosynthesis. …

Iodine enters the circulation as plasma inorganic iodide, which is cleared from circulation by the thyroid and kidney. The iodide is used by the thyroid gland for synthesis of thyroid hormones, …

Iodide oxidation and organification occur mainly in the thyrocyte apical surface and these reactions are catalyzed by thyroperoxidase (TPO) in the presence of hydrogen peroxide. Thus, …

Iodine plays a central role in thyroid physiology, being both a major constituent of thyroid hormones (THS) and a regulator of thyroid gland function. This review concerns those aspects …

2014年5月30日 · Iodide is a major regulator of iodide accumulation and organification. Iodine intake has a negative effect on the expression of NIS and high doses of iodide block thyroid …

2024年8月15日 · Iodine is an essential element required for the propagation of chemical reactions that are needed to create the thyroid hormones Thyroxine (T 4) and Triiodothyronine (T 3). …