Neurofibromas are benign (noncancerous) tumors that grow on nerves in the body. They consist of an overgrowth of nerve tissue along with blood vessels and other types of cells and fibers.

A neurofibroma is a benign tumor that develops along your nerve cells. This tumor is a symptom of a group of rare, inherited conditions called neurofibromatosis. People born with neurofibromatosis may have tumors on their skin, under their skin or deeper in their bodies. Most neurofibromas don’t cause medical problems.

A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor[1] or sporadic neurofibroma[1]), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease.

2024年10月5日 · A neurofibroma is a type of peripheral nerve tumor that forms a soft bump on or under the skin. The tumor can develop within a major or minor nerve anywhere in the body. This common type of nerve tumor tends to form centrally within the nerve.

2023年8月8日 · Neurofibromas are the most common peripheral nerve sheath tumor and are often found either by patients or during routine skin exams. These lesions appear as soft, skin-colored papules or small subcutaneous nodules. There are three main types of neurofibromas: localized, diffuse, and plexiform.

Neurofibromas are slow-growing tumors that arise from Schwann cells which normally wrap around nerves and provide a variety of supportive functions. Neurofibromas can occur along any of the peripheral nerves, which include the cranial nerves that transmit information between the brain and parts of the head and neck.

2024年8月9日 · Neurofibromas are benign (WHO grade 1) peripheral nerve sheath tumors that are usually solitary and sporadic. There is, however, a strong association with neurofibromatosis type 1 (NF1), particularly for the plexiform subtype. Neurofibromas are generally divided into five morphological forms 1-8:

The term neurofibromatosis refers to two different genetic diseases characterized by skin abnormalities and nervous system tumors: Neurofibromatosis type 1: Also called NF-1 or Von Recklinghausen’s disease. Neurofibromatosis type 2: Also known as NF-2. Tumor location depends on the type of neurofibromatosis present.

Neurofibromas are the most prevalent benign peripheral nerve sheath tumor. They affect men and women equally, with no racial or ethnic predilection. The age of onset is extremely variable, but localized lesions are most common in adults between 20 and 40.

2024年5月6日 · Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise from benign plexiform neurofibroma (PN) and borderline atypical neurofibroma (AN) in the setting of neurofibromatosis type 1. PN and AN are challenging to monitor for transformation. MPNSTs are best treated at centers with multidisciplinary expertise in management.