微核 - 百度百科
微核（micronucleus, 简称MCN），也叫卫星核，是真核类生物细胞中的一种异常结构，是染色体畸变在间期细胞中的一种表现形式。 微核往往是各种理化因子，如辐射、化学药剂对分裂细 …
Causes and consequences of micronuclei - PMC
Micronuclei are small membrane bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long …
Science 背靠背 | ROS诱发微核包膜的破裂与修复异常的分子机制探 …
2024年10月21日 · 微核崩溃将微核DNA释放到胞质溶胶中，导致DNA损伤、染色体重排和基因组不稳定，从而促进癌症进展。 微核的破裂还激活了先天免疫系统的一个组成部分，激活cGAS …
Micronuclear collapse from oxidative damage | Science - AAAS
Micronuclear collapse exposes the encapsulated DNA to the cytosol, catalyzing chromosomal rearrangements and epigenetic alterations that drive tumor heterogeneity as well as therapy …
Causes and consequences of micronuclei - PubMed
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long …
Small but mighty: the causes and consequences of micronucleus …
2020年11月24日 · Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the main nucleus. They are frequently found in pathologies, including cancer. It …
Micronuclear collapse mechanisms in cancer | Science - AAAS
2024年8月29日 · Unlike the primary nucleus of a cell, micronuclei frequently undergo irreparable rupture and collapse. This breakdown releases micronuclear DNA into the cytosol, causing …
Causes and consequences of micronuclei - ScienceDirect
2021年6月1日 · Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. …
A road to rupture: New insights into the loss of micronuclear …
2024年11月7日 · Micronuclei (MNs) are small cytoplasmic DNA bodies that contain nuclear chromatin that has been excluded from the primary nucleus. MNs arise primarily when (1) …
Fate of micronuclei and micronucleated cells - ScienceDirect
2017年1月1日 · Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. They arise in dividing cells from acentric chromosome fragments or whole …