Metalation (Alt. spelling: Metallation) is a chemical reaction that forms a bond to a metal. This reaction usually refers to the replacement of a halogen atom in an organic molecule with a …

Metalation in chemistry refers to the substitution of hydrogen atoms in a molecule with metal atoms, typically achieved by depositing metal atoms onto a substrate or by evaporating metal …

metalation, any chemical process by which a metal atom is introduced into an organic molecule to form an organometallic compound, but more commonly the process involving a …

The direct metalation group (DMG) is typically a Lewis basic moiety that interacts with the Lewis acidic lithium cation allowing for deprotonation by the alkyl-lithium species from the nearest …

邻位定向金属化反应 (DoM)是基于芳香族亲电取代反应的一种变化反应：亲电试剂通过芳基锂化合物中间体，仅与定向金属化基团或称DMG的邻位发生取代。 DMG与锂通过一个 杂原子 相互 …

The term metalation denotes the replacement of hydrogen by metal to yield a true organometallic compound. The replacement of hydrogen by metal in a compound such as acetoacetic acid is …

Metalation is a term used in chemistry to describe the process of introducing a metal atom or ion into an organic molecule. This process has revolutionized the field of chemistry by enabling …

2014年11月14日 · One of the most widely applied chemical reactions is metalation (1, 2), in which an inert carbon-hydrogen (C-H) bond is transformed to a more reactive carbon-metal (C-M) …

2020年4月24日 · The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled …

Understanding the metalation mechanism opens up avenues for developing novel synthetic methods that utilize metal reagents to target specific C-H bonds in complex molecules. By …