- Polycythemia vera is a myeloproliferative disorder associated with a Janus kinase-2 (JAK2) mutation that causes the neoplastic proliferation of the hematopoietic progenitor cells.www.ncbi.nlm.nih.gov/books/NBK557660/
Polycythemia vera: 2024 update on diagnosis, risk ... - PubMed
- DOI: 10.1002/ajh.27002
- 已发布: 2023/9
- Keywords: Polycythemia vera (PV) is a JAK2-mutated my…
- Authors: Ayalew Tefferi
- 页数: 23
Disease overview: Polycythemia vera (PV) is a JAK2-mutated myeloproliferative neoplasm characterized by clonal erythrocytosis; other features include leukocytosis, thrombocytosis, splenomegaly, pruritus, constitutional symptoms, microcirculatory disturbances, and increased risk of thrombosis and pro...JAK2 Negative Polycythemia Vera - PubMed Central (PMC)
Polycythemia vera (PV) is a stem cell disorder, characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. Several reasons suggest that a mutation on the Janus kinase …
Polycythemia Vera - StatPearls - NCBI Bookshelf
2023年4月24日 · Polycythemia vera is a myeloproliferative disorder associated with a Janus kinase-2 (JAK2) mutation that causes the neoplastic proliferation of the hematopoietic …
JAK2 Gene Mutation: Causes and Related Conditions - Verywell …
- The most common JAK2 mutation found in blood disorders is known asJAK2 V617F, named for a mutation at a specific location in the JAK2gene. Rather than being inherited, JAK2 V617Fmutations are acquired, occurring at random. As they occur in cells that do not produce eggs or sperm, the mutation is not passed on to a person's children. The mutation is...
Identification of an Acquired JAK2 Mutation in Polycythemia Vera
By sequencing the entire coding regions of cDNAs of candidate enzymes, we identified a G:C-to-T:A point mutation of the JAK2 tyrosine kinase in 20 out of 24 PV blood samples but none in …
Genetic Background of Polycythemia Vera - PubMed Central (PMC)
Polycythemia vera belongs to myeloproliferative neoplasms, essentially by affecting the erythroblastic lineage. JAK2 alterations have emerged as major driver mutations triggering PV …
- 其他用户还问了以下问题
Polycythemia vera (PV) is one of four JAK2 mutation-prevalent myelo-proliferative neoplasms (MPN), which also include essential thrombo-cythemia (ET), primary myelofibrosis (PMF), and …
JAK2 Exon 12 Mutated Polycythemia Vera: The Mayo …
2017年12月7日 · The main objective of the current study was to identify consecutive cases of JAK2 exon 12 mutated PV from two centers of excellence in myeloproliferative neoplasms and compare their natural history with their …
JAK2 Exon 12 Mutations in Polycythemia …
JAK2 exon 12 mutations were identified in eight of an additional nine patients who received a diagnosis of V617F-negative polycythemia vera from their local physicians.
JAK2 exon 12 mutations in polycythemia vera and idiopathic ...
2007年2月1日 · Results: We identified four somatic gain-of-function mutations affecting JAK2 exon 12 in 10 V617F-negative patients. Those with a JAK2 exon 12 mutation presented with …