Immune checkpoint - Wikipedia
Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance , which prevents the immune system from attacking cells indiscriminately. However, …
Immune checkpoint signaling and cancer immunotherapy
2020年5月28日 · In this review, we discuss regulation of immune checkpoint signaling at multiple levels to provide an overview of our current understanding of checkpoint biology. Topics …
Immune checkpoint proteins: Signaling mechanisms and ...
Immune checkpoint proteins (ICP) are currently one of the most novel and promising areas of immune-oncology research. This novel way of targeting tumor cells has shown favorable …
Immune Checkpoint Inhibitors - NCI - National Cancer Institute
Immune checkpoint inhibitors are a type of immunotherapy that block immune checkpoint proteins from binding with partner proteins. Learn about the cancers treated with checkpoint inhibitors …
Immune Checkpoints - an overview | ScienceDirect Topics
Immune checkpoints play an essential role in the activation of T cells, as T cell activation requires the recognition of protein peptides presented by MHC and the co-stimulation of CD28 on …
Immune Checkpoints, a Novel Class of Therapeutic Targets for ...
One of these mechanisms is immune checkpoints (ICPs). The roles of ICPs in maintaining immune tolerance and hence suppressing autoimmunity were revealed in animal models and …
Immune checkpoint proteins: exploring their therapeutic ...
In this review, we highlight the latest advances on the role of immune checkpoint proteins, such as OX40–OX40L, CTLA‐4 and TIM proteins, in atherosclerosis and discuss their therapeutic …