Microglia: A Double-Edged Sword in Intracerebral Hemorrhage ... - PubMed
- DOI: 10.3389/fimmu.2021.675660
- 已发布: 2021/05/06
- Keywords: intracerebral hemorrhage; microglia; neuroimm…
- Authors: Jiachen Liu
- 页数: 1
Microglia are the resident immune cells of the central nervous system (CNS). It is well established that microglia are activated and polarized to acquire different inflammatory phenotypes, either pro-inflammatory or anti-inflammatory phenotypes, which act as a critical component in the neuroinflamma...Microglia Phenotype and Intracerebral Hemorrhage: A …
In this review, we describe the dualistic roles of microglia in ICH from an immunological perspective, expound on the detailed mechanism of perihematomal microglial activation and polarization, and summarize the …
Modulators of microglial activation and polarization after ...
2017年5月19日 · Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and …
- 作者: Xi Lan, Xiaoning Han, Qian Li, Qing Wu Yang, Jian Wang
- Publish Year: 2017
Microglia Phenotype and Intracerebral Hemorrhage: A Balance of …
2021年10月13日 · In this review, we discuss the dual functions of microglia in the brain after an ICH from immunological perspective, elaborate on the activation mechanism of perihematomal …
- 作者: Rentang Bi, Zhi Fang, Mingfeng You, Quanwei He, Bo Hu
- DOI: 10.3389/fncel.2021.765205
- Publish Year: 2021
- Publication: Front Cell Neurosci. 2021; 15: 765205.
Modulators of microglial activation and polarization after ...
This Review summarizes key studies on modulators of microglial activation and polarization after ICH, including M1-like and M2-like microglial phenotype markers, transcription factors and key …
- 作者: Xi Lan, Xiaoning Han, Qian Li, Qing Wu Yang, Jian Wang
- Publish Year: 2017
Frontiers | Microglia: A Double-Edged Sword in …
2021年5月5日 · Microglia produce pro-inflammatory mediators at the early stages after ICH onset, anti-inflammatory microglia with neuroprotective effects appear to be suppressed. Previous research found that driving microglia towards an anti …
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Frontiers | Neuroinflammation of microglia polarization …
2022年10月10日 · During the ICH progress, microglial activation and polarization modulators have clinical and translational implications, including critical signaling pathways, transcription factors (TFs), and particularly microglia M1- and M2 …
Phenotype change of polarized microglia after intracerebral …
2020年9月1日 · As the major immune cells that participate in the post-ICH inflammation, microglia have received increasing attention. ICH-induced microglial activation demonstrates a duality in …
Mechanism and Regulation of Microglia Polarization in …
Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, but effective treatments are lacking, and neuroinflammation plays a key role in the pathogenesis. In the innate immune …
Microglial Responses after Ischemic Stroke and Intracerebral …
This review summarizes the literature on microglial responses after ischemic stroke and ICH, highlighting the mediators of microglial activation and potential therapeutic targets for each …
