Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. [1][2] Featuring a main globular domain and a long N-terminal tail, H3 is involved with the …

There are five families of histones, which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer.

Histone H3 is a core histone that, along with other histones, forms the nucleosome, which is a fundamental unit of chromatin. It plays a crucial role in gene transcription regulation and is …

In this review, we describe the attributes of histone H3 mutants identified in cancer. H3 mutants were first identified in genes encoding H3.3, in pediatric high-grade glioma, and subsequently …

Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev. 19, 1761 …

H3.3 is the most common non-centromeric variant of histone H3 that differs from the canonical H3 by just 4–5 amino acids. Here we discuss the current knowledge of H3.3 in transcriptional …

H3.3 is the most common non-centromeric variant of histone H3 that differs from the canonical H3 by just 4–5 aa. Here, we discuss the current knowledge of H3.3 in transcriptional regulation …

Histones and their variants endow chromatin with unique properties and show a distinct distribution into the genome that is regulated by dedicated deposition machineries. The …

Polyclonal Antibody for studying H3. Validated for WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Histone H3 Antibody (CST #9715) is ready to ship.

2023年4月12日 · Histone H3 variants constitute a perfect example of the intricate systems of histone supply, with various histone chaperones responsible for the correct deposition of H3 in …