High endothelial venules (HEV) are specialized post-capillary venules characterized by plump endothelial cells as opposed to the usual flatter endothelial cells found in regular venules. [1] HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV). [2] [3]In humans, HEVs are found in all secondary lymphoid organs (with …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillance for foreign invaders (bacterial and viral ...

2024年1月24日 · High endothelial venules (HEVs) are specialized blood vessels that support the migration of lymphocytes from the bloodstream into lymph nodes (LNs). They are also formed ectopically in mammalian organs affected by chronic inflammation and cancer. The recent arrival of immunotherapy at the forefront of many cancer treatment regimens could boost ...

High endothelial venules display a unique specialization of blood endothelial cells and due to their explicit interaction with lymphocytes, only arise in specific lymphoid organs during development. The fact that they can also ectopically develop in non-lymphoid organs during chronic (tumor) inflammation in the adult is again linked to their ...

2021年8月17日 · High endothelial venules (HEVs) are specialized postcapillary venules composed of cuboidal blood endothelial cells that express high levels of sulfated sialomucins to bind L-Selectin/CD62L on lymphocytes, thereby facilitating their transmigration from the blood into the lymph nodes (LN) and other secondary lymphoid organs (SLO). ...

High Endothelial Venules: Lymphocyte Traffic Control and Controlled Traffic* Georg Kraal, Reina E. Mebius, in Advances in Immunology, 1997. XIV Concluding Remarks. High endothelial venules are important structures involved in the immunological surveillance of our body as essential traffic control sites in the recirculation of lymphocytes. Already critically important during the …

2023年12月1日 · High endothelial venules (HEVs), high-walled cuboidal blood vessels, through their expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells into primary, secondary, and tertiary lymphoid structures (TLSs) (aka tertiary lymphoid organs). HEV heterogeneity exists between various lymphoid organs in their expression of ...

2020年10月29日 · High endothelial venules (HEVs) are specialised postcapillary venules that specifically serve this function and are found in all SLOs except spleen. It is becoming clear that alterations to HEV network density and/or morphology can result in immune activation or, as recently implicated, in providing an exit route for tumour cell dissemination ...

2019年3月12日 · High-endothelial venules (HEVs) are anatomically distinct post-capillary venules specialized in lymphocyte trafficking that are found in lymph nodes and other secondary lymphoid organs (with the exception of spleen; Girard et al., 2012; Girard and Springer, 1995; Rosen, 2004).HEVs play a critical role in immunity by allowing recirculation (homing) of naive …

2023年2月23日 · The lack of sufficient intratumoral CD8 + T lymphocytes is a significant obstacle to effective immunotherapy in cancer. High endothelial venules (HEVs) are organ-specific and specialized postcapillary venules uniquely poised to facilitate the transmigration of lymphocytes to lymph nodes (LNs) and other secondary lymphoid organs (SLOs).