The oncogene HER2; Its signaling and transforming functions and …
The HER family proteins are type I transmembrane growth factor receptors that function to activate intracellular signaling pathways in response to extracellular signals. Their structure …
HER2 信号转导通路 | Cell Signaling Technology
ErbB 受体信号通过 Akt、MAPK 以及其他多种通路来调节细胞增殖、迁移、分化、凋亡以及细胞移动。 在多种形式的恶性肿瘤中，ErbB 家族成员以及其部分配体通常过表达、扩增或突变，这 …
Molecular Pathways and Mechanisms of HER2 in Cancer Therapy
In HER2-amplified cancers HER3 is tightly linked with downstream PI3K-AKT signaling in a pathway that involves robust compensatory feedback regulation. As such, inhibition of HER2 …
HER 2: Biology, Detection, and Clinical Implications - PMC
The estrogen receptor (ER) and the HER2 (c-erbB2, HER2/neu) signaling pathways are the dominant drivers of cell proliferation and survival in the majority (85%) of breast cancers. …
HER2 - Wikipedia
Signaling pathways activated by HER2 include: [16] In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be …
HER2 Signaling Pathway | Cell Signaling Technology
ErbB2 lacks a known ligand, but recent structural studies suggest its structure resembles a ligand-activated state and favors dimerization. The ErbB receptors signal through Akt, MAPK, and …
A Comprehensive Review of HER2 in Cancer Biology and …
2024年7月11日 · HER2-activating mutations contribute to accelerated tumorigenesis and metastasis. This review provides an overview of HER2 biology, signaling pathways, …
Molecular Pathways and Mechanisms of HER2 in Cancer Therapy
2023年7月5日 · The oncogene ERBB2 encoding the receptor tyrosine-protein kinase erbB-2 (HER2) is frequently overexpressed or amplified and occasionally mutated in a variety of …
HER2 signaling pathway. HER2 as well as the other
HER2 as well as the other members of the EGFR family are receptor tyrosine kinases which are located on the cell membrane and responds to a wide variety of ligands. Phosphorylation of the...
(PDF) Role of HER2 signaling pathway in breast cancer: Biology ...
2012年10月1日 · Human epidermal growth factor receptor 2 (HER2), a member of the ErbB family of transmembrane receptor tyrosine kinases, is amplified in 20–30% of invasive breast …