2024年10月18日 · Our study establishes a pipeline to profile highly diverse isoforms using state-of-the-art long-read sequencing, builds a landscape of alternative splicing in the mouse heart during MI and IR.

2024年10月18日 · Our study establishes a pipeline to profile highly diverse isoforms using state-of-the-art long-read sequencing, builds a landscape of alternative splicing in the mouse heart during MI and IR. © 2024. The Author (s).

2024年12月25日 · HAO1 (Hydroxyacid Oxidase 1) is a Protein Coding gene. Diseases associated with HAO1 include Nephrolithiasis, Calcium Oxalate, 1 and Primary Hyperoxaluria. Among its related pathways are Glyoxylate metabolism and glycine …

2022年12月27日 · Here, we report the transcriptional profile of the murine heart from early embryogenesis to late neonatal stages. Through further analysis of this dataset, we identify several transcriptional...

2023年11月28日 · Through designing the isolation procedure of neonatal mouse cardiac cells, we provide detailed cellular atlases of the heart at single‐cell resolution across 4 different stages after birth. We have obtained 10 000 cardiomyocytes; to our knowledge, this is the most extensive reference framework to date.

2022年1月15日 · Here we show that expression of hydroxyacid oxidase 1 (Hao1), a gene identified in a previous genome-wide association study (GWAS) as an OPLL-associated candidate gene, specifically and significantly decreased in …

2024年12月17日 · Electrophoretic variants are known for this locus. The a allele determines a fast migrating band in BALB/c, CBA/H, C3H/He and C57BL/6; the b allele, a slow band in NZC; the …

Our study identifies a nodal role of NFYa in regulating pre-natal cardiac growth and a previously unrecognized transcriptional control mechanism of heart metabolism, highlighting the importance of mitochondrial metabolism during heart development and regeneration. Cardiomyocytes (CMs) are specialized heart cells with contrac-tile functions.

HAO1-1 achieves rapid and durable target knockdown in mice. Wild-type mice were injected with a single i.v. dose of HAO1-1 at 0.3 or 1 mg/kg. (a) At the indicated time points, five animals were...

Although the focus of this atlas is on the descriptive anatomic and histological development of the normal mouse heart from E11.5 to E18.5, potential embryonic cardiac lesions are discussed with a list of the most common transgenic pre- and perinatal heart defects.