H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. [5]

H2 antagonists block histamine-induced gastric acid secretion from the parietal cells of the gastric mucosa (lining of the stomach). H2 antagonists are used to treat gastroesophageal reflux disease (GERD), gastrointestinal ulcers and other gastrointestinal hypersecretory conditions.

2024年12月8日 · H2 receptor blockers are drugs that are used to treat gastroesophageal reflux disease (GERD) and peptic ulcers. This drug is effective, cheap, and safe for relieving heartburn.

2024年3月18日 · H2 blockers are medications that suppress stomach acid production. They’re a short-term treatment for stomach ulcers, duodenal ulcers and acid reflux. You can get them over the counter or by prescription. Brands include Tagamet®, Pepcid® and Axid®. What are H2 blockers (H2 antagonists)?

2023年3月28日 · Histamine regulates countless bodily functions and plays a key role in your body’s inflammatory response. The effect histamine has depends on which histamine receptors it binds to. Researchers have identified four types of histamine receptors.

2024年8月11日 · H2 receptor blockers, or histamine-2 receptor antagonists (H2RAs), are gastric acid-suppressing agents frequently used to treat various gastric conditions.

The H 2 antagonists are competitive antagonists of histamine at the parietal cell's H 2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid.

2018年1月25日 · The selective histamine type 2 receptor antagonists/blockers (H2 blockers) are widely used in the treatment of acid-peptic disease, including duodenal and gastric ulcers, gastroesophageal reflux disease and common heartburn.

Histamine receptor 2 (HR2) activation mediates early desensitization of basophils. The initial decrease in basophil activity is also associated with symptom scores in grass pollen immunotherapy. H2R suppresses allergen-associated FcεRI-mediated basophil activation. HR2 mainly plays a role in immune tolerance mechanisms.

H 2 receptors are found in the gastrointestinal tract and are the main mediators of gastric acid secretion. H 3 receptors are expressed on histamine-containing neurons and act as presynaptic autoreceptors that mediate feedback inhibition of histamine release and synthesis.