Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol...

Gestodene achieves contraceptive efficacy with the lowest dose of any progestin in a COC, and has an established and favorable short- and long-term tolerability profile. In this review we present an overview of the pharmacology, potency and tolerability of gestodene.

2014年4月1日 · Gestodene achieves contraceptive efficacy with the lowest dose of any progestin in a COC, and has an established and favorable short- and long-term tolerability profile. In this review we present an overview of the pharmacology, potency and tolerability of gestodene.

The newer progestogens gestodene, desogestrel and norgestimate were developed in an attempt to produce agents with more selective progestational activity that would improve cycle control and minimise metabolic changes and adverse events while effectively preventing pregnancy. In …

Gestodene, one of three new gonane progestins, is the most potent on a per weight basis in regard to progestational effects and has little or no estrogenic effect. In in vivo animal studies, gestodene also has less androgenic activity compared with progestins found in older combination oral contraceptive formulations.

2023年5月10日 · Gestodene, one of three new gonane progestins, is the most potent on a per weight basis in regard to progestational effects and has little or no estrogenic effect. In in vivo animal studies, gestodene also has less androgenic activity compared with progestins found in older combination oral contraceptive formulations.

2012年10月22日 · Gestodene is an active progestogen whereas the other 2 new progestogens desogestrel and norgestimate are prodrugs. As with other progestogens, the pharmacokinetics of gestodene show considerable intra- and interindividual variation. Gestodene has high oral bioavailability (almost 100%) and exhibits dose-linear pharmacokinetics.

Gestodene has a positive pharmacokinetic profile, characterized by its high bioavailability and prolonged half-life, both of which contribute to its contraceptive efficacy. Gestodene is the most potent of all the progestins used in COCs based on its oral dose required to inhibit ovulation.

2013年6月24日 · Gestodene achieves contraceptive efficacy with the lowest dose of any progestin in a COC, and has an established and favorable short- and long-term tolerability profile. In this review we present an overview of the pharmacology, potency and tolerability of gestodene.

2024年9月13日 · Gestodene is a potent synthetic progesterone called progestogen. Gestodene is almost always used in the combined pill alongside synthetic oestrogens and is exclusively used orally. Gestodene is thought to have no or weak androgenic activity, so it’s often recommended for use by people who prefer a less-androgenic contraceptive 1 .