Genetic Mutations | Types of Mutations | American Cancer Society
Mutations are abnormal changes in the DNA of a gene and can sometimes lead to cancer. Find out common causes.
COSMIC | Catalogue of Somatic Mutations in Cancer
COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Start …
Mutational landscape of cancer-driver genes across human …
2023年8月7日 · In this study, we investigate the genomic sequences of 20,331 primary tumours representing 41 distinct human cancer types to identify and catalogue the driver mutations …
The Genetics of Cancer - National Cancer Institute
Scientists have found hundreds of DNA and genetic changes (also called variants, mutations, or alterations) that help cancer form, grow, and spread. Cancer-related genetic changes can …
A compendium of mutational cancer driver genes - Nature
2020年8月10日 · In this Review, we present the Integrative OncoGenomics (IntOGen) pipeline, an implementation of such an approach to obtain the compendium of mutational cancer drivers. …
A compendium of mutational cancer driver genes - PubMed
2020年8月20日 · In this Review, we present the Integrative OncoGenomics (IntOGen) pipeline, an implementation of such an approach to obtain the compendium of mutational cancer drivers. …
The Mutational Spectra of Cancer Genes in TCGA Data
2017年5月10日 · Here we present graphical representations of TCGA data on eight major cancer genes: BRAF, TP53, PIK3CA, PTEN, EGFR, and the three RAS genes themselves, KRAS, …
Mutational landscape of cancer-driver genes across human cancers
2023年8月7日 · In this study, we investigate the genomic sequences of 20,331 primary tumours representing 41 distinct human cancer types to identify and catalogue the driver mutations …
A multiscale functional map of somatic mutations in cancer
2025年1月24日 · A major goal of cancer biology is to understand the mechanisms driven by somatically acquired mutations. Two distinct methodologies—one analyzing mutation …
Fusion genes in cancers: Biogenesis, functions, and therapeutic ...
2025年1月20日 · The processes of tumorigenesis and development are intricate, involving numerous genes and molecular pathways. Fusion genes, direct products of abnormal …