2021年3月14日 · Transcription factor forkhead box P1 (FOXP1) is a crucial modulator in skeletal development and aging. Here, we determined the role and regulatory mechanisms of FOXP1 in osteosarcoma. Higher FOXP1...

由于p21是p53肿瘤抑制因子的转录靶点，由于基因毒性应激暴露，p21在含有稳定p53的细胞中表达增加。 在所有成人组织中都有表达，在大脑中表达水平降低5倍。 由p53/TP53、mezerin (抗白血病化合物)和IFNB1激活其表达。 被HDAC1抑制表达。 通常细胞核定位。 细胞质（通过PIM1磷酸化p21 Thr-145导致p21向细胞质转移，增强了p21蛋白的稳定性）。 图二：p21靶点ICC实验结果图，Anti-p21产品 (ab109520)。 蓝色：DAPI；红色：alpha Tubulin；绿色：p21。 …

Taken together, we demonstrate that FOXP1, which is transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, suggesting that FOXP1 is a potential target for osteosarcoma therapy.

2005年11月1日 · C-Fos expression correlated significantly with cell-cycle promoters (cyclins E and B1, cdk2 and cdk4) and cell-cycle inhibitors (p16, p21, Rb). The latter proteins are often paradoxically upregulated in human malignant carcinomas, indicating that their proliferation-inhibiting function can be overrun in tumour cells.

FOXP1 在骨肉瘤细胞系中的过表达和敲低表明 FOXP1 促进增殖、肿瘤球形成、迁移和侵袭，并抑制失巢凋亡。 从机制上讲，FOXP1 充当 P21 和 RB（视网膜母细胞瘤蛋白）转录的阻遏物，并直接与肿瘤抑制因子 p53 相互作用以抑制其活性。 细胞外信号调节激酶/c-Jun N-末端激酶 (ERK/JNK) 信号和 c-JUN/c-FOS 转录因子被发现是 FOXP1 的上游激活剂。 此外，通过慢病毒或腺相关病毒 (AAV) 介导的 shRNA 递送使 FOXP1 沉默抑制细胞来源和患者来源的异种移植动 …

目的 探讨EGFR、HER2、c-jun、c-fos、P21、P16、P53在非小细胞肺癌(NSCLC)中的表达及临床病理特征.方法 采用荧光原位杂交技术(FISH)和免疫组织化学法(SP)检测64例非小细胞肺癌组织中EGFR、HER2、c-jun、c-fos、P21、P16、P53的表达.结果 (1)64例NSCLC中,EGFR和HER2阳性扩增率分别为39. ...

Luteolin blocks the acetylation of histone H4 and regulates the expression of c-FOS, p21, and other genes playing key roles in the epidermal growth factor receptor signaling pathway and in cell...

2003年8月28日 · The c-fos, p21 gene expression were detected by Western blot, and cell cycle analyzed. Result It was revealed that both HMBA-Ⅰ,HMBA-Ⅱ as well as HMBA exerted growth inhibition effect on K562 cells and the expression of p21 and c-fos proteins were increased.

2013年9月16日 · These data demonstrate that rapid early epidermal responses to rasHa/fos/ΔPTEN co-operation involve induction of p53/p21 to alter differentiation and divert excessive proliferation into cyst...

2008年12月1日 · Using site-directed mutagenesis, a DNA affinity precipitation assay, and functional assays, we demonstrated that phosphorylation of the C-terminus of c-Fos (Thr 232, Thr 325, Thr 331, and Ser 374) plays an important role in its binding to the p21 promoter, and in conjunction with N-terminus phosphorylation of c-Fos (Ser 70) to transactivate p21 ...