Aberrant epigenetic modifications are reversible, allowing excellent opportunities for therapeutic intervention. Nowadays, several epigenetic drugs are used worldwide to treat, e.g., myelodysplastic syndromes and leukemias.

2019年12月2日 · Here, we describe the timeline of epigenetic drug discovery and development beginning with the early design based solely on phenotypic observations to the state-of-the-art rational epigenetic drug discovery using validated targets.

Epigenetic therapy refers to the use of drugs or other interventions to modify gene expression patterns, potentially treating diseases by targeting epigenetic mechanisms such as DNA methylation and histone modifications.

2024年11月26日 · Epigenetic modifications are a fundamental mechanism regulating gene expression, crucial for various cellular functions. Dysregulated epigenetic regulators, whether overexpressed or...

Epigenetic drugs (epidrugs) are chemical compounds that alter DNA and chromatin structure, promoting the disruption of transcriptional and post-transcriptional modifications, mainly by regulating the enzymes necessary for their establishment and maintenance, reactivating epigenetically silenced tumor-suppressor and DNA repair genes [63,64].

2016年5月23日 · The so-called epigenetic drugs are a relatively new class of drugs acting on chromatin enzymatic and non-purely enzymatic complexes, for which interest has grown exponentially in the last decade. Indeed, huge research efforts have been initiated within academia to address chemical as well as biological aspects of epigenetic drugs and their targets.

Epigenetic drugs are usually chemical substances that modify the defects in post-modifications in histones or DNA. In this review, the latest knowledge about the correlation between epigenetic defects and cancer/neurodegeneration disorders as well as information about the drugs to treat specific epigenetic errors has been provided. Funding ...

2023年8月1日 · Epigenetic drugs (Chemical or naturally derived) are used alone or together with chemotherapy or immunotherapy to enhance antitumor effects, reduce drug resistance and stimulate the host immune response.

It is known that the occurrence and development of cancer can be controlled by regulating unexpected epigenetic events. Epi-drugs are used singly or in combination with chemotherapy and enhance antitumor activity, reduce drug resistance, and stimulate the host immune response.

From DNA methylation to histone modifications, from chromatin remodelling to noncoding RNAs, all these chemical marks and molecules facilitate the correct reading of our genetic material. The epigenetic setting sits between the genotype and the phenotype to originate cellular homeostasis.