Targeting GPX4 in human cancer: Implications of ... - ScienceDirect
2023年4月10日 · GPX4 transcription is stimulated by CREB elevated in lung adenocarcinoma through the CREB-E1A binding protein P300 (EP300) binding [63]. Human GPX4 promoter is …
EP300 stimulates CREB-dependent GPX4 transcription. (A
CREB has been confirmed to be involved in the transactivation of GPX4 [18, 20, 37] to further identify VTN-regulated GPX4-mediated ferroptosis that could be attributed to CREB. As shown …
The Role of CREBBP/EP300 and Its Therapeutic Implications in ...
CREBBP/EP300 participate in tumor immune regulation by modulating the function of immune cells through various pathways. T regulatory cells (Tregs) are a subset of CD4 + T-cells with …
CREB stimulates GPX4 transcription to inhibit ferroptosis in …
It was observed that CREB suppressed lipid peroxidation by binding the promoter region of glutathione peroxidase 4 (GPX4), and this binding could be enhanced by E1A binding protein …
Analysis and therapeutic targeting of the EP300 and CREBBP
2022年12月1日 · In the current study, we investigated the physiological roles of EP300 and CREBBP in both ALCL and HL, and exploited the therapeutic potential of EP300/CREBBP …
CREB 刺激 GPX4 转录以抑制肺腺癌中的铁死亡。,Oncology …
2021年4月13日 · 据观察，creb 通过结合谷胱甘肽过氧化物酶 4 (gpx4) 的启动子区域来抑制脂质过氧化，并且这种结合可以通过 e1a 结合蛋白 p300 (ep300) 增强。 CREB 中的 bZIP 结构域和 …
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer
2017年3月1日 · p300 and CREB-binding protein (CBP), two homologous lysine acetyltransferases in metazoans, have a myriad of cellular functions. They exert their influence mainly through …
CREB stimulates GPX4 transcription to inhibit ferroptosis in lung ...
It was observed that CREB suppressed lipid peroxidation by binding the promoter region of glutathione peroxidase 4 (GPX4), and this binding could be enhanced by E1A binding protein …
The epigenetic regulators EP300/CREBBP represent promising
2024年5月1日 · Here, we demonstrated that EP300 and CREBBP are core epigenetic regulators in the pathogenesis of MLL-r AML through assaying the transposase-accessible chromatin …
CREBBP/EP300 mutations promoted tumor progression in diffuse ... - PubMed
2021年1月11日 · In B-lymphoma cells, the mutation or knockdown of CREBBP or EP300 inhibited H3K27 acetylation, downregulated FBXW7 expression, activated the NOTCH pathway, and …