2016年7月18日 · We found that in hepatoma HepG2 cells, cystine (oxidized form of cysteine) activated mTORC1 and suppressed the ISR. Cystine deprivation induced GSH efflux and …

2021年12月8日 · Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is …

Life-threatening hepatotoxicity in the setting of acetaminophen (APAP) overdose is due to depletion of glutathione (GSH), a vital cysteine-containing tripeptide that protects cells and …

The tripeptide, γ- l -glutamyl- l -cysteinyl-glycine known as glutathione (GSH) (Fig. 1), is the most important low molecular weight antioxidant synthesized in cells. It is synthesized by the …

GSH maintains the redox state in cells by acting as a major antioxidant, and detoxifies xenobiotics through GSH conjugation. GSH also acts as a donor substrate of a γ-glutamyl group and a …

2022年8月24日 · Cysteine might scavenge free radicals and is a limiting substrate for the cellular synthesis of glutathione (GSH). We investigated the association of cysteine with oxidative …

Methionine and cysteine are constituents of glutathione. To understand the effects of these two sulfur amino acids on the glutathione (GSH)-dependent detoxification defense system, …

2025年2月3日 · Cysteine, a rate-limiting precursor for GSH, shares GSH’s antioxidant properties. In tumor cells under high OS, endogenously synthesized cysteine is inadequate to counteract …

2021年3月4日 · Cysteine supports several vital cellular functions, primarily the generation of the tripeptide antioxidant GSH 5. Stable isotope tracing revealed that starved cells engaged in …

GSH equivalents circulate in the blood predominantly as cystine, the oxidized and more stable form of cysteine. Cells import cystine from the blood, reconvert it to cysteine (likely using …