Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors.

2024年12月24日 · CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Tongue Carcinoma and Laryngeal Squamous Cell Carcinoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Loss of proteins required for interphase microtubule organization from the centrosome.

Cyclin B1 and its catalytic partner CDK1 belong to the fundamental kinase machinery regulating the progression from G2 to mitosis. Also known as the mitotic promoting factor (MPF), cyclin B1/CDK1 phosphorylation governs key steps for mitotic entrance featured by the nuclear envelope breakdown, spindle formation, and chromatin condensation [56].

2024年9月6日 · Cyclin B1 (CCNB1) encodes a regulatory protein essential for the regulation of cell mitosis, particularly in controlling the G2/M transition phase of the cell cycle.

Cyclin B1 is an essential protein that is thought to be responsible for most of the other actions of Cdk1 in the cytoplasm and nucleus [11]. The localization of cyclin B1 is subject to extensive regulation and is the major focus of this review.

2008年1月15日 · Cyclin B1 is a key regulatory protein controlling cell cycle progression in vertebrates. Cyclin B1 binds CDK1, a cyclin-dependent kinase catalytic subunit, forming a complex...

We found that Cyclin B1 must be exported from the nucleus for the cell to prevent premature entry to mitosis, and retaining Cyclin B1–Cdk1 at the plasma membrane precludes entry to mitosis.

2024年9月4日 · CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression 1. Here we demonstrate that CDK5 is active during mitosis and is necessary for...

The cyclin B1 gene codes a protein that allows cell cycle progression through the G2/M-phase checkpoint so that mitosis occurs, and is overexpressed in some types of cancer, such as squamous cell carcinoma of the esophagus [18].

2025年1月5日 · Expression of Cyclin B1 correlated with differentiation and vascular invasion in NSCLC; Cyclin B1 overexpression associated with higher mean values for Ki-67 proliferative index and proliferating cell nuclear antigen labeling index and poorer prognosis.