A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides, cyclic nucleotides are composed of three functional groups: a sugar, a nitrogenous base , …

2022年9月21日 · The intracellular small molecules 2′,3′-cyclic nucleotide monophosphates (2′,3′-cNMPs) have recently been rediscovered within both prokaryotes and eukaryotes. Studies in bacteria have demonstrated that 2′,3′-cNMP levels affect bacterial phenotypes, such as biofilm formation, motility, and growth, and modulate expression of numerous ...

The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense.

2022年11月15日 · Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP.

2022年11月11日 · A pioneering report by Sutherland and Rall almost 65 years ago revealed that extracellular hormones regulate mammalian cellular physiology via the production of 3′,5′-cyclic adenosine monophosphate (3′,5′-cAMP) second messenger. 1 3′,5′-cAMP and 3′,5′-cGMP form the paradigmatic nucleotide second messengers, which control many ...

2017年10月4日 · The cyclic nucleotide monophosphates (cNMPs), and notably 3',5'-cyclic guanosine monophosphate (cGMP) and 3',5'-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic d …

Cyclic nucleotide monophosphates (cNMPs) and the enzymes that can generate them are of increasing interest in the plant sciences. Arguably, the major recent advance came with the release of the complete Arabidopsis thaliana genome that has enabled the systematic search for adenylate (ACs) or guanyla …

2018年4月30日 · Unusual 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) recently were quantified in mammalian systems, and previous reports have linked these nucleotides to cellular stress and damage in eukaryotes, suggesting an intriguing connection with nucleotide/nucleoside pools and/or cyclic nucleotide signaling.

2016年12月7日 · The 2′,3′-cyclic nucleoside monophosphates (2′,3′-cNMPs) of adenosine, guanosine, cytidine, and uridine were prepared in good yield in a one pot reaction from unprotected ribonucleosides and activated trimetaphosphate in the presence of N-methylimidazole, 4-nitroimidazole and MgCl 2.

2017年10月3日 · The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense.