2001年1月29日 · The crystal structure of human muscle creatine kinase has been determined by the molecular-replacement method and refined at 3.5A resolution. The structures of both the monomer and the dimer closely resemble those of the …

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP).

The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.

肌酸激酶[1] （creatine kinase，CK）又称 肌酸磷酸激酶 （creatine phosphokinase，CPK）， EC 2.7.3.2，是可逆地催化 ATP 及 肌酸 之间 转磷酸 反应的酶。 肌酸激酶催化肌酸（Cr）的轉化，並利用三磷酸腺苷生成 磷酸肌酸 （PCr）和 二磷酸腺苷 （ADP）。 肌酸激酶属于细胞能量代谢的关键 激酶，與 細胞 內能量運轉、 肌肉收縮 、 三磷酸腺苷 （ATP）再生有直接關係 [2]。 肌酸激酶根据分布的部位可分为肌肉型（M型）、脑型（B型）和线粒体型（Mt型）肌酸激酶 同工酶。

We have solved the structure of the octameric mitochondrial isoform, Mib-CK, which is located in the intermembrane compartment and along the cristae membranes. Mib-CK consumes ATP produced in the mitochondria for the production of phosphocreatine, which is then exported into the cytosol for fast regeneration of ATP by the cytosolic CK isoforms.

We have solved the structure of the octameric mitochondrial isoform, Mih-CK, which is located in the intermembrane compartment and along the cristae mem branes. Mih-CK consumes ATP produced in...

1998年9月28日 · The crystal structure of rabbit muscle creatine kinase, solved at 2.35 A resolution by X-ray diffraction methods, clearly identified the active site with bound sulfates surrounded by a constellation of arginine residues. The putative binding site of creatine, which is occupied by a sulfate group in this analysis, has been tentatively identified.

The crystal structure of human muscle creatine kinase has been determined by the molecular-replacement method and refined at 3.5A resolution. The structures of both the monomer and the dimer closely resemble those of the other known structures in the creatine kinase family.

1996年5月23日 · We have solved the structure of the octameric mitochondrial isoform, Mib-CK, which is located in the intermembrane compartment and along the cristae membranes. Mib-CK consumes ATP produced in the mitochondria for the production of phosphocreatine, which is then exported into the cytosol for fast regeneration of ATP by the cytosolic CK isoforms.

2012年1月1日 · In this paper we will include a brief summary of the history of the detection of creatine kinases isoforms, their main structural features, physical and catalitic properties and multiple...