In molecular biology, circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together.

2021年1月8日 · circRNAs （CircularRNAs，环形RNA分子） 是一类不具有5‘ 末端帽子和3’ 末端poly (A)尾巴、并以共价键形成环形结构的客观存在于生物体内的非编码RNA分子。 二、circRNA的发现. 1976年，在电子显微镜下观测到真核细胞的细胞质中存在环状RNA分子。 1993年，在小鼠中发现其Sry基因存在环状转录。 2012年，借助于高通量测序技术，circRNA被大量发现。 2013年，Nature杂志同一期刊登两篇circRNA研究文章 （图1，图2） ，自此circRNA相关 …

2024年11月11日 · Once thought to be artefacts of splicing gone wrong, circular RNAs (circRNAs) are now known to be widespread across the tree of life. They’ve been implicated in conditions including cancer,...

2024年11月13日 · 尤其是环状RNA（circular RNA, circRNA）的发现，极大地扩展了我们对RNA生物学的理解。 这些RNA分子通过独特的剪接机制形成闭合环状结构，类似分子折纸

Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′ or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA degradation by exonucleases, thereby empowering them with high pharmaceutical stability and biostability relative to current standard-of-care linear mRNA.

Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions.

2024年12月13日 · Circular RNA (circRNA) is a candidate for next-generation messenger RNA therapeutics owing to its remarkable stability. Here we describe trans-splicing-based methods for the synthesis...

2018年10月5日 · CircRNA are known as micro RNA (miRNA) sponges due to their ability to bind to miRNA molecules and influence their function. They play a key role in the regulating miRNA target genes. Due their...

2022年5月17日 · Emerging applications of RNA circles to interfere with cellular processes, modulate immune responses, and direct translation into proteins shed new light on biomedical research. In this review, we discuss approaches used in circular RNA studies and the current understanding of their regulatory roles and potential applications.

2020年12月14日 · Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs.