2013年1月1日 · In our view, a channelopathy is a disease that affects channel function and, by doing so, compromises the patient’s clinical status. When this happens indirectly, through other mechanisms, it is fascinating — and still is a channelopathy.

Channelopathies are a group of genetic, autoimmune, or inflammatory conditions that alter cardiomyocyte ion channel function in a manner that predisposes to bradyarrhythmias or tachyarrhythmias in the absence of a structural heart disorder. Sudden cardiac death may occur.

Channelopathies are a group of diseases caused by the dysfunction of ion channel subunits or their interacting proteins. These diseases can be inherited or acquired by other disorders, drugs, or toxins. Mutations in genes encoding ion channels, which impair channel function, are the most common cause of channelopathies. [1] .

Channelopathies are diseases that develop because of defects in ion channels caused by either genetic or acquired factors (Fig. 1). Mutations in genes encoding ion channels, which impair channel function, are the most common cause of channelopathies.

Ion channels in the myocardial cellular membrane are responsible for allowing the cardiac action potential. Genetic abnormalities in these channels can predispose to life-threatening arrhythmias.

A channelopathy is a defect in one or more of the microscopic channels in the walls of heart cells through which electrolytes such as sodium, potassium, and calcium enter and leave the cells. It is this flow of electrolytes that is responsible for the normal electrical activity of the heart.

2024年2月15日 · Cardiac channelopathies are a group of disorders that affect the electrical signals in the heart. This article provides an overview of the causes, symptoms, and treatment options for cardiac channelopathies, helping patients understand and manage these conditions.

A channelopathy is a disorder that occurs when a person's ion channels do not work properly. What are ion channels? An ion is a molecule in our body that helps conduct messages. For example a chloride ion or sodium ion.

A channelopathy refers to the clinical abnormalities caused by mutations in genes that affect the channels in the body, including those in the heart and sensory-neuromuscular system.

2023年10月16日 · The first use of the term “channelopathy” dates to three decades ago. Discoveries unraveling channelopathies and their impacts on human health continue to expand. This is, in part, attributed to recent advances in our understanding of the role of ion channels in human physiology and pathophysiology and high-throughput genetic screens of ...