Casein kinase 2 (CK2) is a ubiquitously expressed, constitutively active Ser/Thr protein kinase that performs diverse functions related to cell survival and tumorigenesis.

2021年5月17日 · CK2 (previously called casein kinase 2 or CK-II) is one of the first identified protein kinases. 1 It phosphorylates hundreds of physiological substrates, 2 and is one of the major contributors...

Protein kinase CK2 ('casein kinase II') has traditionally been classified as a messenger-independent protein serine/threonine kinase that is typically found in tetrameric complexes consisting of two catalytic (alpha and/or alpha') subunits and two regulatory beta subunits.

The casein kinase 2 (CK2) complex, crucial for eukaryotic growth, differentiation, and metabolic regulation, presents a promising therapeutic target for various human diseases, including cancer, diabetes, and obesity.

2024年2月14日 · The casein kinase 2 (CK2) complex has garnered extensive attention over the past decades as a potential therapeutic target for diverse human diseases, including cancer, diabetes, and obesity, due to its pivotal roles in eukaryotic growth, differentiation, and …

The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase overexpressed in various human carcinomas and its high expression often correlates with poor prognosis.

Casein Kinase-2 (CK2) is an active serine/threonine kinase which phosphorylates numerous substrates and accounts for a large proportion of the eukaryotic phosphoproteome. The potent anti- apoptotic role of CK2 is making it a more attractive therapeutic target in cancer biology [186].

2023年7月21日 · The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid leukemia (AML), which is an aggressive bone marrow malignancy.

In this review article, the authors summarize all research conducted to date on the protein CK2 (Casein Kinase 2), an aggregate of multiple proteins that form a complex including two copies each of CK2α and CK2β, and how it relates to various human diseases.

Protein kinase CK2 (also termed casein kinase-2 or -II) is a ubiquitous Ser/Thr-specific protein kinase required for viability and for cell cycle progression. CK2 is especially elevated in proliferating tissues, either normal or transformed, and …