2021年1月13日 · Disruption of mitochondrial membrane potential is a potent trigger of mitophagy (Elmore et al, 2001). CCCP, a proton‐selective ionophore, and antimycin A (an inhibitor of the …

CCCP and FCCP are now being increasingly used for investigating the mechanisms of autophagy by inducing mitochondrial degradation through the disruption of the mitochondrial membrane …

Mitochondrial dysfunction mediated by CCCP (carbonyl cyanide m-chlorophenyl hydrazone), an inhibitor of mitochondrial oxidative phosphorylation, evokes the integrated stress response …

2021年6月19日 · Our results provide a precise and noninvasive technology for research on mitophagy, which stimulates target mitochondria with little damage, and reveal mitoCa 2+ …

2018年3月1日 · We found that CCCP decreased mitochondrial membrane potential, resulting in mitochondrial dysfunction. CCCP increased PGAM5, dynamin-related protein 1 (DRP1), and …

2018年2月1日 · The mitophagy or autophagy response is induced and amplified by (i) the electrophilic properties of the lipophilic weak acids CCCP and FCCP; (ii) the production of …

2017年1月19日 · Current approaches to initiate mitophagy include acute dissipation of the mitochondrial membrane potential (ΔΨ m) by mitochondrial uncouplers (for example, …

2022年5月20日 · In mammals, CCCP is normally used as a mitochondrial autophagy inducer to elicit PINK1-induced mitophagy (Shin and Chung, 2020; Soutar, et al., 2019). In this study, …

2024年11月20日 · We discovered that CCCP caused mitochondrial dysfunction in HSCs supported by increased mitochondrial ROS (mtROS) and depolarized mitochondrial …

Using LC3 as the marker for autophagy activation, we found that CCCP induced GFP-LC3 punctation and the formation of lipidated LC3 in a dose-dependent (Fig. 1, A-C and …