Antibodies against C1q—a subcomponent of C1, the first component in the complement cascade—are markers of proliferative LN. The antibodies impede the ability of C1q to bind, …

Anti-C1q antibody (Anti-C1q Ab) develops in disorders characterized by immune complex mediated injury, more commonly in skin and glomerular microvasculature. 1 Anti-C1q Ab are …

By far the largest set of studies focus on anti-C1q antibodies is systemic lupus erythematosus (SLE). In SLE anti-C1q antibodies associate with involvement of lupus nephritis in such a way …

Supplementary test information for C1q Antibody, IgG such as test interpretation, additional tests to consider, and other technical data.

C1q Antibody (IgG) - This assay serves as a non-invasive aid for the diagnosis of active proliferative lupus nephritis (LN) and for monitoring disease activity. Autoantibodies to C1q …

The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the …

The presence of the anti-C1q IgG antibody may be associated with increased risk of lupus nephritis or with systemic lupus erythematosus (SLE) global activity. Anti-C1q antibodies are …

Recent research indicates that anti-C1q antibodies bind specifically to solid-phase C1q rather than fluid-phase C1q, potentially leading to the exposure of cryptic epitopes that enhance Fc …

Anti-C1q antibodies have been found to be prevalent in hypocomplementemic urticarial vasculitis syndrome (also referred to as anti-C1Q vasculitis) as well as in some patients with systemic …

C1q recognizes and binds to immunoglobulin complexed to antigen and initiates the complement cascade. Congenital deficiencies of any of the early complement components (C1, C2, C4) …