As BRD4 directly interacts with MYC and is involved in upregulation of MYC target gene, BRD4 may function with MYC to properly modulate RNA pol II initiation, topoisomerase function, …

2020年6月16日 · The MYC stabilizing kinase, ERK1, regulates MYC levels directly and indirectly by inhibiting BRD4 kinase activity. These findings demonstrate that BRD4 negatively regulates …

2018年5月18日 · BRD4 and MYC (as a dimer with MAX; not shown here) are broadly bound to the regulatory regions of active genes. Whereas BRD4 degradation affects transcription of all …

BRD4, a driver of oncogenesis that activates Myc transcription, is being investigated as a therapeutic target in MYC-driven cancers. We report that BRD4 directly destabilizes MYC …

2023年10月24日 · Mechanistically, NPM1 influences and cooperates with BRD4 to facilitate c-Myc transcription to promote PCa progression. In addition, JQ1, a bromodomain and extra …

2022年7月28日 · The BRD4-specific inhibitor JQ1 suppressed cell proliferation and colony formation and triggered cell apoptosis, cell cycle arrest, and changes in the expression of …

Down-regulation of BRD4 influences c-Myc expression and PI3K/AKT/mTOR pathway. JQ1 has been reported to exert its antitumor effects by suppressing c-Myc expression in other solid …

2025年1月23日 · Brd4 is a transcriptional regulator that recognizes acetylated histones and is known to be involved in inflammatory responses. The role of Brd4 in CRC development …

Chromatin immunoprecipitation-qPCR and luciferase assays show that BRD4 binds to and coordinately activates c-MYC promoter, indicating that c-MYC is transcriptional target of BRD4 …

2018年4月5日 · We found that BRD4 acts as general coactivator of RNA polymerase II–dependent transcription, which is broadly repressed upon high-dose BETi treatment. At …