This introductory section will outline the role played by the ureohydrolase enzyme arginase in health and disease, emphasizing the involvement of arginase in disease and injury conditions that affect the cardiovascular system, the kidneys, neoplastic malignancies, and the brain and retina.

Arginase is the enzyme that converts L-arginine to urea and L-ornithine, functions important for protection against NH 3 toxicity and cell growth and repair. Excessive arginase activity has been linked to cardiovascular diseases due to actions in reducing the supply of L-arginine needed by nitric oxide (NO) synthase to produce NO

Arginase: from urea cycle enzyme to immune cell component. The enzyme arginase hydrolyzes L-arginine to the products L-ornithine and urea. In mammals, two arginase isoenzymes (designated arginase I and II) exist.

Arginase is a manganese-containing enzyme that catalyzes the breakdown of l-arginine into urea and l-ornithine. It plays a crucial role in the urea cycle and is found in various tissues in the body, with different isozymes serving specific functions. AI generated definition based on: Toxicological Survey of African Medicinal Plants, 2014

2018年4月1日 · Here, we review the involvement of arginase in diseases affecting the cardiovascular, renal, and central nervous system and cancer and discuss the value of therapies targeting the elevated activity of arginase.

2022年10月8日 · Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine.

The urea cycle arginase (arginase I or liver arginase) is cytosolic, and is the best characterized of the mammalian arginases. A second isozyme, arginase II or kidney arginase, is mitochondrial in location.

2024年10月17日 · Arginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysregulation is commonly observed in cancer, autoimmune disorders and ...

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former provides protection against NH3; the latter serves to stimulate cell growth and other physiological functions.

Arginase regulating various cellular functions and processes (senescence, apoptosis, proliferation, inflammation, and autophagy) plays key roles in the pathogenesis of cardiovascular diseases, such as hypertension, atherosclerosis, stroke, …