Conversion of Carboxylic Acids to Amides. The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate.

Conversion of Carboxylic Acids to Amides. The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate.

2020年4月1日 · To investigate the contribution of chemical transformations to properties, we developed a string-based notation and used an enumerative combinatorics approach to produce a map of conceivable...

2019年10月7日 · Amide hydrolysis using aqueous acid (or, alternatively, strong base) gives carboxylic acids. Full mechanism, examples, and applications (strecker synth)

Without DCC, the amine deprotonates the carboxylic acid instead of a nucleophilic attack on the C=O. So, DCC has two main functions; 1) getting rid of the acidic proton, and 2) converting the oxygen into a good leaving group.

2022年9月12日 · In the case of making amides from carboxylic acids, the difficulty comes because the carboxylic acid is a stronger acid (pK a ~5) than the ammonium salt (pK a ~10). The result is that there is very little amine and carboxylic acid at equilibrium. so there is very little nucleophile present.

2023年5月24日 · Carboxylic acids are organic compounds which contain a carboxyl group (-COOH). When a carboxylic acid and amine react, they form a compound called an amide. The reaction between a carboxylic acid and an amine is a nucleophilic acyl substitution reaction.

2024年2月3日 · Herein we conduct a thorough exploration of amine–acid reaction space via systematic enumeration of reactions involving a simple amine–carboxylic acid pair. This approach to chemical space...

2023年5月15日 · Amines react with carboxylic acids at an elevated temperature, undergoing condensation and forming an amide. The reaction cannot occur at room temperature as amines deprotonate carboxylic acids resulting in the formation of the highly unreactive carboxylate ion.

To investigate the contribution of chemical transformations to properties, we developed a string-based notation and used an enumerative combinatorics approach to produce a map of conceivable amine-acid coupling transformations, which can …