2014年1月1日 · Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chylomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver.

1999年12月1日 · The mechanisms regulating the synthesis and secretion of apolipoprotein (apo) B-100 and apoB-48 are incompletely understood but are of importance because elevated levels of apoB, the main protein in LDL, are associated with an increased risk of coronary heart disease. 1 ApoB exists in 2 forms in plasma, apoB-100 and apoB-48, 2 both of which are ...

2023年1月15日 · apoB48 is a trafficking handle and a direct biomarker for chylomicrons. Simple, rapid apoB48 immunoassay can be of value (relative to the gold-standard test, gel lipoprotein electrophoresis) in the diagnosis of chylous effusions of origin.

Apolipoprotein B is a non-exchangeable apolipoprotein found in two forms in humans, apolipoprotein B-48 and apolipoprotein B-100. Apolipoprotein B-48 is synthesized in enterocytes and is essential for the assembly and secretion of chylomicrons to the blood [1,2].

2015年3月19日 · Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake …

2016年1月1日 · Chylomicrons containing apoB-48 are secreted from the intestine during the postprandial state, whereas very low density lipoproteins (VLDL) containing apoB-100 are constitutively formed in the liver.

2023年9月14日 · Interestingly, apolipoprotein B-48 (ApoB-48), a chylomicron structural protein, is exclusively synthesized and secreted by the enterocytes. During meal absorption, lipids are transferred to the endoplasmic reticulum, where triglycerides, cholesterol, and phospholipids are associated with ApoB-48 to form a prechylomicron [15].

2020年7月7日 · Fatty meals induce intestinal secretion of chylomicrons (CMs) containing apolipoprotein (Apo) B48. These CMs travel via the lymphatic system before entering the circulation. ApoB48 is produced after post-transcriptional RNA modification by Apobec-1 editing enzyme, exclusively in the small intestine of humans and most other mammals.

2007年9月1日 · Apo B-48 in the developing small intestine is regulated in a manner that optimizes chylomicron formation. Apobec-1 expression is upregulated before parturition in the small intestine in rodents, swine, and humans to switch from apo B-100 production in the fetal gut to apo B-48 in the neonatal intestine (23).

ApoB-48 is synthesized by bound ribosomes in the rough endoplasmic reticulum (RER). Lipid droplets, presumed to be chylomicron precursors, are observed within the lumen of the RER and the smooth endoplasmic reticulum (SER) and mature chylomicrons accumulate in the lumen of the trans-Golgi, before release at the lateral border of the enterocyte.