WPNT (channel 22) is a television station in Pittsburgh, Pennsylvania, United States, affiliated with The CW and MyNetworkTV. It is owned by Sinclair Broadcast Group alongside Fox affiliate WPGH-TV (channel 53). The two stations share studios on Ivory Avenue in the city's Summer Hill section, where WPNT's transmitter is also located.

The myofibroblast stromal cell line, WPMY-1, was derived from stromal cells from the same peripheral zone of the histologically normal adult prostate, as that used for RWPE-1 cells (ATCC CRL-11609).

1999年7月1日 · These epithelial and myofibroblast cell lines, derived from the same prostate, provide novel and useful models for studies on paracrine stromal–epithelial interactions in carcinogenesis, tumor progression, prevention and treatment of prostate cancer and benign prostatic hyperplasia.

WPMY-1 cells secrete very low levels of MMP-9 but high levels of MMP-2, markedly higher than the epithelial cells. These epithelial and myofibroblast cell lines, derived from the same prostate, provide novel and useful models for studies on paracrine stromal-epithelial interactions in carcinogenesis, tumor progression, prevention and treatment ...

In this study, prostate microtissues composed of human derived stromal (WPMY-1) and epithelial (RWPE-1) cell lines grown in scaffold-free hydrogels were developed and characterized using immunohistochemistry, light microscopy, and qRT-PCR.

WPMY-1 cells expressing mock, PRA or PRB were transiently transfected with control siRNA or siRNA against PR for 48 hours. PR knockdown efficiency was confirmed by western blotting with PR antibody (B) and by real-time PCR (C).

2024年8月8日 · WISP1 upregulation is essential for inducing immune checkpoints and immunosuppressive cytokines via LIF/LIFR signaling and STAT3 phosphorylation. This process leads to increased neuroendocrine markers, immune checkpoints, cell proliferation, and migration.

2021年1月15日 · The expression profiles of circRNAs, lncRNAs and mRNAs in WPMY-1-derived exosome-like vesicles (WPMY-1-exo) were explored by high-throughput RNA sequencing. Firstly, both TE-WPMY-1 and TE-WPMY-1-exo significantly promoted RWPE-1 cells proliferation.

2024年3月22日 · In this study, we expand this information by examining how chronic Cd exposure affects prostate-derived myofibroblast (WPMY-1) cells transforming into a cancer-associated fibroblast like phenotype.

2016年5月5日 · WPMY-1 stromal cells expressing ps20 were characterised by transcriptome microarray and the function of WPMY-1 conditioned media on growth of PCa cell lines was assessed.