2020年5月20日 · Resting T cells become activated after stimulation by cognate antigen in the context of an antigen-presenting cell and co-stimulatory signals. Activated T cells produce and consume...

2022年12月28日 · Improvements in tumor immunotherapies depend on better understanding of the anti-tumor T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8 + T cells in TDLNs shared functional, transcriptional, and epigenetic traits with TCF1 + stem-like cells in the tumor.

This review addresses all the strategies targeting tumor pathogenesis, including metabolic pathways, to evaluate the clinical significance of current and future immunotherapies for patients with cancer, which are further engaged in T cell activation, differentiation, and …

2023年1月10日 · By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8 + T cells in TDLNs shared functional, transcriptional, and epigenetic traits with TCF1 + stem-like cells in the tumor. The phenotype and TCR overlap suggested that these TDLN cells were precursors to tumor-resident stem-like CD8 + T cells. Murine tumor models ...

2024年7月18日 · Current immunotherapy efforts rely on harnessing the pool of tumor-reactive T cells to provide targeted, durable protection against tumors. These approaches include cancer vaccines,...

2020年9月15日 · Even if CD8 + T cells manage to penetrate the fibrotic extracellular matrix tumour barrier, they need to upregulate the activity of metabolic pathways and remain activated under these demanding...

2024年5月16日 · We show that therapy-induced intratumoral CD8 + T cells recruited and skewed late-stage activated M1-like macrophages, which were critical for effective tumor control in two different murine models of cancer immunotherapy. The activated CD8 + T cells summon these macrophages into the tumor and their close vicinity via CCR5 signaling.

2024年4月12日 · The binding of ITPRIPL1 extracellular domain to CD3ε on T cells significantly decreased calcium influx and ZAP70 phosphorylation, impeding initial T cell activation. Treatment with a neutralizing antibody against ITPRIPL1 restrained tumor growth and promoted T cell infiltration in mouse models across various solid tumor types.

2024年6月10日 · We show that therapy-induced intratumoral CD8 + T cells recruited and skewed late-stage activated M1-like macrophages, which were critical for effective tumor control in two different murine models of cancer immunotherapy. The activated CD8 + T cells summon these macrophages into the tumor and their close vicinity via CCR5 signaling.

T-cell bispecific antibodies (TCB) are novel antibody constructs capable of binding simultaneously to T cells and tumor cells, allowing cross-linking and the formation of immunologic synapses. This in turn results in T-cell activation, expansion, and tumor killing.