In the ligand-dependent pathway, when progesterone binds to the inactive PR, it causes a conformational change and releases the chaperone. It then dimerizes and binds to …

In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain, a hinge section, and a C-terminal ligand binding domain. A …

2019年8月19日 · Progesterone receptor (PGR) co-ordinately regulates ovulation, fertilisation and embryo implantation through tissue-specific actions, but the mechanisms for divergent PGR …

Like all nuclear receptors, progesterone receptors (PR) are transcription factors that consist of a DNA binding domain (DBD), sandwiched between an upstream N-terminal region that contains …

Progesterone receptors (PRs) recognize and bind to DNA in a sequence-specific manner. To define the sequence-specific determinants of PR binding to DNA, we employed a detailed …

孕酮受体 （英語： progesterone receptor，缩写 PR，也被称为 NR3C3 ，nuclear receptor subfamily 3, group C, member 3，即 核受体 第三亚族C组成员3）是一种细胞内蛋白质，由 甾 …

2023年11月29日 · As with all nuclear hormone receptors, progesterone signals by binding to its receptor, PR, which leads to dimerization and nuclear translocation of the hormone-bound …

Progesterone receptor (PR) mediates the transcriptional effects of the steroid hormone progesterone, which plays a key role in development, differentiation, and maintenance of …

Progesterone receptor (PGR) encodes a nuclear steroid receptor transcription factor which is induced in response to LH in the granulosa cells of preovulatory follicles. PGR mediates the …

For example, progesterone can bind neuronal σ1 receptors and modulate glutamate signaling while the progesterone metabolite, allopregnanolone, is a potent modulator of the GABA type …