An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the orexin receptors, OX 1 and OX 2. [1]

Orexin antagonists are medications for treating insomnia. Orexin, also known as hypocretin, is a neurotransmitter secreted in the hypothalamus region of the brain. Neurotransmitters are substances that nerve cells (neurons) release to transmit signals to each other.

2022年5月13日 · Currently, three orexin receptor antagonists—suvorexant, lemborexant, and daridorexant—are FDA approved for the treatment of insomnia (TABLE 2). 30-32 Several orexin receptor antagonists are being investigated for insomnia in Alzheimer’s disease, appetite suppression in obesity, and a number of mental-health conditions, including ...

2025年1月24日 · Compare the cost of prescription and generic Orexin Receptor Antagonists medications. See information about popular Orexin Receptor Antagonists, including the conditions they treat and alternatives available with or without insurance.

Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS. A orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.

Dual orexin receptor antagonists (DORA) developed for insomnia antagonise orexin 1 and orexin 2 receptors. These drugs have been shown to increase sleep onset time and sleep duration . They also reduce the level of stress hormones, cortisol and norepinephrine (NE), and anxiety and depression in psychiatric patients with depression.

In this review article, the potential of orexin receptor antagonists—primarily dual orexin receptor antagonists (DORAs)— is discussed as an additional pharmacological option for treatment of insomnia.

In this article, we review the neurobiology of orexin signaling, recent preclinical and clinical studies with orexin antagonists, and potential applications of these compounds for the treatment of insomnia and other disorders. Orexin-A and -B are derived …

Dual orexin receptor antagonists (DORAs) have been approved for the treatment of insomnia disorders (suvorexant, lemborexant) and drugs with a distinctive profile (daridorexant) or orexin-2 receptor selectivity (seltorexant) are in development.

Orexin is a neuropeptide released by the lateral hypothalamus that regulates the sleep–wake cycle and sustains wakefulness. Antagonists to orexin receptors—orexin-1 and orexin-2—have become a pharmacologic target for inducing sleep and the treatment of insomnia. Two medications of this class are currently available on the US market.