2022年12月14日 · Neural stem cells have two primary functions: self-renewal and differentiation. This guide summarizes the most commonly used markers of neural stem cells and their immediate progeny. Although the ultimate goal of any stem cell is to differentiate, all stem cell populations, including neural stem cells, must balance this fate with self-renewal.

中枢神经系统 (CNS) 和周围神经系统 (PNS) 细胞最初通过形态学检测，而现在则通过在正常或疾病状态下对各类型细胞都具有的特异性蛋白检测。 表达的空间和时间变化使这些标记物描述更加复杂，而且这些变化还受遗传和表观遗传级联的调节。 尽管十分错综复杂，但仍在胚胎形成、成体神经发生和神经退行性疾病的发病机理中发现了 CNS 和 PNS 细胞的许多生物标记物。 哺乳动物神经系统的所有神经元均起源于神经干细胞，神经干细胞有自我更新和多潜能性的特征。 在神 …

Despite these intricacies, numerous biomarkers have been discovered for CNS and PNS cells during embryogenesis, adult neurogenesis, and the pathogenesis of neurodegenerative disorders. All neurons of the mammalian nervous system originate from neural stem cells, which are characterized by self-renewal and multipotency.

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. Changes in the expression levels of specific molecules help to identify the presence of neural stem cells in studies focused on further differentiation toward specific neural lineages. Commonly used markers for neural stem cells include ...

Neural stem cell (NSCs) can be identified via their expression of specific cellular markers. View this interactive graphic to identify NSC markers and relevant R&D Systems products.

Here we gathered and generalized a series of NSC biomarkers emerging during the procedures of embryonic and adult neural stem cell, which may be used to identify the subpopulation cells with distinguishing characters in different timeframes of neurogenesis.

Commonly used markers for neural stem cells include Nestin and SOX2. Nestin is a useful marker because although it is expressed predominantly in stem cells of the central nervous system (CNS), its expression is absent from nearly all mature CNS cells. The transcription factor SOX2 is known to be expressed at high levels in the neuroepithelium ...

Overview of Neural Stem Cells & Lineage-specific Markers. Neural stem cells (NSC) are undifferentiated precursor cells defined by their capacity for self-renewal and mulitpotency. During central nervous system development, NSCs proliferate and divide to generate clonally related progeny that differentiate into neurons, astrocytes ...

Neural stem cell markers and antibodies for prominent neural cell types and targets, including neurons, glial cells, neuronal differentiation markers, Nestin, and SOX2.

Commonly used markers for neural stem cells include Nestin and SOX2. Other protein markers, expressed at the cell surface are, for example, ABCG2, FGFR1 and Frizzled-9. The neurons (nerve cells) are electrically excitable cells that transmit and relay the nerve signal within the central nervous system and in the periphery.