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V617F mutation in JAK2 is associated with poorer survival in …
2006年3月1日 · Most patients with polycythemia vera and half with idiopathic myelofibrosis and essential thrombocythemia have an acquired V617F mutation in JAK2. Using sensitive …
JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic ...
2007年2月1日 · We identified four somatic gain-of-function mutations affecting JAK2 exon 12 in 10 V617F-negative patients. Those with a JAK2 exon 12 mutation presented with an isolated …
Comparative study of different methodologies to detect the JAK2 V617F ...
Overexpression of JAK2 V617F together with the erythropoietin receptor in cells, results in hyperactivation of erythropoietin-induced cell signaling. This gain-of-function mutation of JAK2 …
Turn It Off! Genetic Switch System Suggests Targeting of Mutant JAK2 ...
2024年4月10日 · The authors confirmed that JAK2 V617F excision reverted the MPN phenotype regardless of TET2 status, suggesting that specific and potent inhibition of JAK2 V617F can …
The JAK2 V617F somatic mutation, mortality and cancer risk in …
We measured the prevalence of the JAK2 V617F mutation and tested the hypothesis that presence of the mutation is associated with overall mortality, risk of any cancer, hematologic …
How does JAK2V617F contribute to the pathogenesis of …
2014年12月5日 · The recent elucidation of the crystal structure of the JAK2 JH2 domain (in which the V617F mutation occurs) advances the potential for the development of mutant-specific …
JAK2 mutants (e.g., JAK2V617F) and their importance as drug …
In this review we provide an overview of JAK2V617F signaling and its inhibition by small-molecule kinase inhibitors. In addition, myeloproliferative neoplasms are discussed regarding the role of …
Jak2 V617F Reversible Activation Shows Its Essential Requirement …
2024年5月1日 · We show in preclinical models that there is an absolute requirement for JAK2 V617F in MPN cells and that mutant-specific targeting of JAK2 V617F abrogates MPN …
JAK2, the JAK2 V617F mutant and cytokine receptors - PubMed
In JAK2-deficient cells, we showed that JAK2 V617F can transmit signals from ligand-activated TpoR or EpoR. Furthermore, the mutant JAK2 can be demonstrated to stimulate traffic of the …
JAK2 V617F polycythemia vera and essential thrombocythemia
2022年4月8日 · A somatic JAK2 V617F mutation is found in almost all cases of PV and ~60% of ET and PMF resulting in the constitutive activation of JAK-STAT pathway.