2024年9月4日 · We tested CAR’s applicability for challenging mouse and human neurons toward scaled and faithful data production. Three-dimensional (3D) neuron morphometry offers direct insights into the...

a tandem model of the cerebellum (forward + inverse cerebellar modules) has been implemented by means of a realistic point-neuron Spiking Neural Network, embedded with distributed plasticity model and simulate the forward and inverse controller functions of the cerebro-cortical-cerebellar loops in a closed-loop setting, emulating error-based ...

2009年10月14日 · Here we advocate a programme of reverse engineering with the aim of linking patterns of action potentials in distinct nodes of neural circuits to animal behaviour. The circuit diagram, depicting...

2020年6月24日 · Using a chemically induced model of Parkinson’s disease in mouse, we show conversion of midbrain astrocytes to dopaminergic neurons, which provide axons to reconstruct the nigrostriatal...

2014年5月20日 · GABAergic interneuron hypofunction is hypothesized to underlie hippocampal dysfunction in schizophrenia. Here, we use the cyclin D2 knockout (Ccnd2 (-/-)) mouse model to test potential links between hippocampal interneuron deficits and psychosis-relevant neurobehavioral phenotypes.

2016年10月19日 · Inhibition of Nuak1 in fruit flies suppressed neurodegeneration in tau-expressing Drosophila, and Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model. These results demonstrate that decreasing total tau levels is a valid strategy for mitigating tau-related neurodegeneration and reveal Nuak1 to be a novel therapeutic entry ...

To test the ability of the PINN approach to infer models for neuronal dynamics, we integrated the FN model using the scipy [4] odeint function (300 timepoints with initial parameters set as a = 0:3, b = 1:2, I = 0:28, ˝ = 20), and applied our PINN to solve the inverse problem to explore the goodness of t as well as reproducibility.

2022年10月1日 · Mice are the preferred animal species to model human brain disorders, but often fail in translation. Monkeys provide relevant translational information because of their higher brain complexity and homology to humans. The value of comparative studies in lower species is seldom acknowledged by researchers and regulators.

2007年2月23日 · Using a mouse model, we demonstrate robust phenotypic reversal, as activation of MeCP2 expression leads to striking loss of advanced neurological symptoms in both immature and mature adult animals. Mutations in the X-linked MECP2 gene are the primary cause of Rett syndrome (RTT), a severe autism spectrum disorder with delayed onset that affects ...

2008年8月6日 · Internal models are a key concept in motor control, helping explain a myriad of adaptive behaviors, including reaching, walking, and saccadic eye movements. They come in two flavors: inverse and forward models. Inverse models (also known as controllers) take as input a desired trajectory and output the corresponding motor commands.