In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential, caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion ...

2023年9月20日 · Here, we present a sequential procedure for precise analysis of mPSC amplitude distributions for the range of small currents. To illustrate the developed approach, we chose previously obtained...

2015年1月31日 · In the present work, we investigated the possibility of using the characteristics of spontaneous excitatory postsynaptic currents (EPSCs) for estimation of quantum parameters of excitatory synaptic transmission in different types of neurons from rat prefrontal cortex slices.

For an excitatory synapse, the binding of neurotrasmitters induces the opening of cationic channels, which is depolarizing the cell. The induced electrical events are called “excitatory postsynaptic currents” (EPSCs) and “excitatory postsynaptic potentials” (EPSPs).

2024年3月29日 · Spike discharge, miniature excitatory postsynaptic potentials (mEPSPs) and afterhyperpolarizations (AHPs) were monitored during resting activity in both regularly and irregularly discharging...

3 天之前 · To record miniature excitatory postsynaptic currents, TTX (1 μM) and the GABA A receptor antagonist bicuculline (10 μM) were applied to the ACSF and mCherry-positive neurons were held at -70 mV.

Miniature post-synaptic currents (mPSCs) have become a primary measure of synaptic modification during development, plasticity, and disease. ‘Minis’ represent the response of postsynaptic receptors to the sponta-neous fusion of vesicles.

2010年7月20日 · Miniature post-synaptic currents (mPSCs) have become a primary measure of synaptic modification during development, plasticity, and disease. ‘Minis’ represent the response of postsynaptic receptors to the spontaneous fusion of vesicles.

3 天之前 · Compared with wild-type animals, cpx-1(ok1552) increased the frequency and amplitude of miniature postsynaptic currents (mPSCs) (Fig 2A–2C). Conversely, the evoked excitatory postsynaptic current (eEPSC) recorded in cpx-1(ok1552) mutants was drastically lower than that recorded in wild-type animals (Fig 2D–2F). Thus, C.

In the present study, we have monitored miniature excitatory postsynaptic potentials/currents (mEPSPs/mEPSCs) and action potential firing in MCNs of the SON, and have observed an activity-dependent change in the properties of excitatory afferent terminals that may trigger and help maintain firing patterns that optimize peptide release from MCNs.