2021年7月1日 · Intestine-specific reduction of MYC in mice improves high-fat-diet-induced obesity, insulin resistance, hepatic steatosis and steatohepatitis. Mechanistically, reduced expression of MYC in...

Intestine-specific reduction of MYC in mice improves high-fat-diet-induced obesity, insulin resistance, hepatic steatosis and steatohepatitis. Mechanistically, reduced expression of MYC in the intestine promotes glucagon-like peptide-1 (GLP-1) production and secretion.

2007年3月21日 · Therefore, to elucidate the role Myc has in the intestine after Apc loss, we have simultaneously deleted both Apc and Myc in the adult murine small intestine. Here we show that loss of...

2025年1月2日 · Intestinal stem cells (ISCs) from GVHD mice have exhibited global transcriptomic changes associated with a substantial Interferon-γ response and upregulation of STAT1. To determine its role in...

2022年2月18日 · Here, we investigated mucosal MYC mRNA expression along the entire intestinal tract in patients with type 2 diabetes and matched healthy controls to elucidate (1) the MYC mRNA expression profile along the intestinal tract of humans and (2) whether intestinal MYC mRNA expression correlates to BMI and/or glycaemic control (HbA1c level).

2007年4月5日 · The proto-oncogene c-MYC has been identified as a target of the Wnt pathway in colorectal cancer cells in vitro, in normal crypts in vivo and in intestinal epithelial cells acutely transformed on in vivo deletion of the APC gene; however, the significance of this is unclear.

By simultaneously deleting both Apc and Myc in the adult murine small intestine, the authors show that loss of Myc rescued the phenotypes of perturbed differentiation, migration, proliferation and apoptosis, which occur on deletion of Apc.

2021年7月1日 · Intestine-specific reduction of MYC in mice improves high-fat-diet-induced obesity, insulin resistance, hepatic steatosis and steatohepatitis. Mechanistically, reduced expression of MYC in...

In this chapter we will provide an overview of our current laboratory protocols to characterize c-Myc function in intestinal homeostasis, regeneration, and tumorigenesis in vivo and in vitro. Within the intestinal epithelium, c-Myc has been characterized as a target of β-catenin-TCF signalling (He et al., Science 281:1509-1512, 1998).

2021年8月17日 · Luo et al. investigated how MYC in the intestine affected lipid metabolism in the liver and the development of nonalcoholic steatohepatitis (NASH), a prevalent metabolic condition lacking treatment options. MYC expression was increased in distal ileum samples from obese individuals and correlated with body mass index (BMI). Similarly, mice on a ...