inotropes and vasopressors target these sites to exert their effects (see Table 1). Vasopressors (norepinephrine, phenylephrine, metaraminol and high dose epinephrine) largely work by stimulating alpha-1 adrenergic receptors, causing peripheral vasoconstriction, increasing SVR and elevating the blood pressure. Increasing SVR, raises the

Inotropes are a group of drugs that alter myocardial contractility by increasing intracellular calcium or enhancing sensitivity to it. However, they may result in suboptimal myocardial oxygen supply demand ratios with impaired diastolic filling and greater arrhythmia risk.

2011年8月1日 · The positive inotropes and vasopressors that are used in anesthesia are sympathomimetics. There are three main adrenergic receptors acted upon by the sympathomimetics: beta-1, beta-2, and alpha receptors.

Inotropes are a heterogenous group of drugs that modify calcium handling and alter the force of myocardial contraction. Catecholamines, and their synthetic analogues, increase intracellular calcium by activating cyclic adenosine monophosphate (cAMP) or inositol triphosphate (IP 3 ).

Inotropic and vasopressor agents are commonly used in the haemodynamic management of patients with cardiovascular compromise. Inotropes are substances that alter myocardial contractility. Positive inotropic agents will increase contractility and …

2024年3月1日 · Inotropes are a group of drugs that alter myocardial contractility by increasing intracellular calcium or enhancing sensitivity to it. However, they may result in suboptimal myocardial oxygen supply demand ratios with impaired diastolic filling and greater arrhythmia risk.

2015年10月1日 · Inotropes are a heterogenous group of drugs that modify calcium handling and alter the force of myocardial contraction. Catecholamines, and their synthetic analogues, increase intracellular calcium by activating cyclic adenosine monophosphate (cAMP) or inositol triphosphate (IP 3).

2009年8月1日 · The widespread use of inotropes in anaesthesia and intensive and coronary care units means that it is important to have a comprehensive understanding of how individual agents achieve their effects. There is growing evidence that these agents can also cause harm secondary to increased ventricular ectopy, tachyarrhythmias and ischaemia.

spinal anaesthesia A patient is scheduled for LSCS under spinal anaesthesia. An iv ifusion is set up and 1000 mls of Hartmanns run in whilst the spinal is performed. The patient is placed supine with a 15-degree left-lateral tilt to minimise aortocaval compression (i.e. pressure from the uterus on the inferior vena cava reducing venous return ...

2019年4月15日 · This chapter reviews the pharmacology of vasopressors and inotropes used commonly in acute care settings and comparable new drugs with promising clinical potential. It focuses on the pharmacodynamic properties of the drugs to a greater degree than their pharmacokinetic properties because most of these drugs have short half-lives, are ...